Selective activity of extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi |
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| Authors: | Fidelis Cho-Ngwa Melanie Abongwa Moses N Ngemenya Kennedy D Nyongbela |
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| Affiliation: | 1.Department of Biochemistry and Microbiology, and Department of Chemistry, Faculty of Science,University of Buea,Buea,Cameroon |
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| Abstract: | Background The current treatment of onchocerciasis relies on the use of ivermectin which is only microfilaricidal and for which resistant parasite strains of veterinary importance are increasingly being detected. In the search for novel filaricides and alternative medicines, we investigated the selective activity of crude extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi, a model parasite for O. volvulus. These plants are used to treat the disease in North West Cameroon. |
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