电针退热时家兔的血浆及脑脊液中前列腺素E_2含量的变化

本实验用家兔复制内毒素性发热模型,观察电针退热时血浆,CSF中PGE_2含量的变化。实验结果表明:在发热高峰期,两组动物的血浆、CSF中PGE_2含量都比发热前明显升高(P<0.091)。电针对内毒素性发热有明显地抑制作用。电针组动物的血浆及CSF中PGE_2含量明显低于对照组(P<0.001)。作者推论:PGE_2是内毒素性发热的一种中枢性发热介质,电针的退热作用可能是通过一种未知方式抑制中枢PGE_2的产生或释放而实现的。

Change of PGE_2 level in the plasma and the CSF in rabbits during the endotoxic fever inhibited by electric acupuncture

Fever was induced by ET in rabbits. The PGE_2 level in the plasma and cerebrospinal fluid (CSF) was measured at peak of fever in both electric acupuncture and control group. The results showed that when the body temperature of animals rose to the peak, the PGE_2 levels in the plasma and CSF were higher than that before fever. (P<0.001). The electric acupuncture could inhibit the febrile response induced by ET. In the electric acupuncture group, the PGE_2 levels in the plasma and CSF were markedly lower than the control group (P<0.001). The authors supposed that PGE, may be a kind of central fever mediator. The depressive effect of electric acupuncture on fever might be related to decrease of PGE, concentration in the plasma and CSF.