心血管介入、血栓抽吸联合替罗非班治疗急性心肌梗死的临床观察

目的探讨心血管介入、血栓抽吸联合盐酸替罗非班治疗急性心肌梗死的临床效果。方法选择本院2010年5月~2012年10月收治的急性心肌梗死患者80例,随机分为观察组和对照组,每组各40例,观察组患者给予替罗非班、血栓抽吸及PCI治疗,对照组患者给予替罗非班及PCI治疗,未进行血栓抽吸。比较两组患者术后即刻TIMI血流分级情况,术后2周测定两组患者的左室射血分数（LVEF）、血浆肌酸磷酸肌酶同工酶（CK-MB）峰值及脑钠肽（BNP）。结果术后血管造影显示观察组患者的TIMI3级血流比例明显高于对照组;LVEF明显高于对照组,CK-MB峰值及BNP明显低于对照组,差异均有统计学意义（P〈0.05）。术后随访1年研究组不良心血管事件发生率低于对照组（P〈0.05）。结论相对于PCI＋替罗非班,PCI及替罗非班联合血栓抽吸治疗急性心肌梗死,可有效改善患者的心功能,减少术后不良心脏事件的发生,值得应用。

Clinical observation of cardiovascular interventions,thrombus aspiration combined tirofiban in treatment of patients with acute myocardial infarction

Objective To investigate the clinical effects Of cardiovascular interventions , thrombus aspiration combined tirofiban in treatment of patients with acute myocardial infarction. Methods 80 Patients with acute myocardial infarction in our hospital from May 2010 to 2012 December were selected and randomly divided into observation group and control group,40 cases in each group,observation group was given tirofiban,thrombus aspiration and PCI treatment and control group was only given tirofiban and PC] treatment.The immediate postoperative TIMI flow grade,left ventricular ejection fraction （LVEF）,plasma creatine phosphate kinase MB （CK-MB） peak and brain natriuretic peptide （BNP） after two weeks in two groups were compared. Results Postoperative angiography showed the percent of patients with TIMI3 blood level was significantly higher than control group,the LVEF was significantly higher,CK-MB peak and BNP. was significantly lower than the control group,the difference was significant （P〈0.05）.1-year postoperative follow-up showed adverse cardiovascular events in observation group was less than the control group （P 〈0.05）. Conclusion Compared with PCI＋ tirofiban,PCI,tirofiban combined with thrombus aspiration in treatment of acute myocardial infarction can effectively improve cardiac function,can reduce the incidence of postoperative adverse cardiac events,it is worthy of application.