| 大黄和早期肠内营养对肠缺血-再灌注损伤大鼠肠屏障功能的影响 |
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| 引用本文： | 杨海波,张静喆,蔡骏,章学林,宋华荣.大黄和早期肠内营养对肠缺血-再灌注损伤大鼠肠屏障功能的影响[J].肠外与肠内营养,2011,18(6):364-367. |
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| 作者姓名： | 杨海波 张静喆 蔡骏 章学林 宋华荣 |
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| 作者单位： | 1. 上海中医药大学附属普陀医院肛肠外科,上海,200062
2. 上海中医药大学附属龙华医院普通外科,上海,200032 |
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| 摘 要： | 目的:观察大黄和早期肠内营养(EEN)对大鼠肠缺血-再灌注损伤(IRI)后肠黏膜屏障的影响.方法:将32只大鼠随机分为对照组、EN组、大黄组、大黄+EN组.在大鼠肠IRI模型上观察再灌注24h后肠黏膜形态学的变化、血清内毒素和细菌易位指标. 结果:肠IRI可导致肠黏膜发生严重损伤.肠IRI后24h,大黄组大鼠内毒素水平...
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| 关 键 词： | 大黄 早期肠内营养 小肠 黏膜屏障 缺血-再灌注损伤 |
Protective effect of Rhubarb and early enteral nutrition on intestinal mucosal barrier injury after ischemia-reperfusion in rats |
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| YANG Hai-bo,ZHANG Jing-zhe,CAI Jun,ZHANG Xue-lin,SONG Hua-rong.Protective effect of Rhubarb and early enteral nutrition on intestinal mucosal barrier injury after ischemia-reperfusion in rats[J].Parenteral & Enteral Nutrition,2011,18(6):364-367. |
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| Authors: | YANG Hai-bo ZHANG Jing-zhe CAI Jun ZHANG Xue-lin SONG Hua-rong |
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| Institution: | 1.Department of Colorectal Surgery,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;2.Department of General Surgery,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China) |
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| Abstract: | Obiective: To observe the effect of Rhubarb and early enteral nutrition on intestinal mucosal barrier injury after intestinal ischemia-reperfusion.Methods: Thirty-two Sprague-dowley rats were randomly divided into control,rhubarb,EN and Rhubarb-EN group.A rat model of intestinal ischemia-reperfusion was constructed by clamping the supramesenteric artery.The rats were killed at the 24th hour after reperfusion.Morphologic changes of intestinal mucosa,endotoxin and bacterial translocation in mesenteric tissue,spleen,and liver were determined. Results: After intestinal ischemia-reperfusion,intestinal mucosa was damaged seriously.At the 24th hour after intestinal ischemia-reperfusion,the level of plasma endotoxin in Rhubarb group was lower than that in EN group(P<0.05).Bacterial translocation was found in all groups.Bacterial translocation decreased significantly in both Rhubarb group and Rhubarb-EN group compared with both control group and EN group.2×2 factorial ANOVA of V/C ratio showed significant synergistic effect in the interaction of factor Rhubarb and EN.Conclusion: Eeffect of early enteral nutrition added Rhubarb on intestinal mucosal barrier injury after ischemia-reperfusion was benefitial in rats. |
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| Keywords: | Rhubarb Early enteral nutrition Intestine Mucosal barrier Ischemia-reperfusion injury |
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