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| 脂联素对糖尿病大血管病变的影响 | |
| 引用本文： | 董源媛,肖新华. 脂联素对糖尿病大血管病变的影响[J]. 国际病理科学与临床杂志, 2008, 28(5): 19-455 |
| 作者姓名： | 董源媛 肖新华 |
| 作者单位： | 南华大学附属第一医院内分泌科,湖南,衡阳,421001;南华大学附属第一医院内分泌科,湖南,衡阳,421001 |
| 基金项目： | 湖南省自然科学基金，湖南省卫生厅课题(2007117) This work Was supported by the Natural Science Foundation of Hunan，the Grant of Hunan Health Bureau of P.R.China |
| 摘 要： | 脂联素(adiponectin，APN)是脂肪细胞分泌的一种细胞因子，通过结合APN受体1和受体2发挥抗炎、抗糖尿病、抗动脉粥样硬化的作用。1型糖尿病病人和正常人的血清APN水平相似，但2型糖尿病病人的APN水平显著降低。2型糖尿病的心血管并发症明显增加，且2型糖尿病合并心血管病变患者的APN水平明显低于2型糖尿病但无心血管病变者，提示糖尿病大血管病变可能与APN缺乏有关。 |
| 关 键 词： | 脂联素 脂联素受体 糖尿病 大血管病变 |
| 收稿时间： | 2008-04-23 |
| 修稿时间： | 2008-05-29 |
Effect of adiponectin on diabetic macro-angiopathy |
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| DONG Yuan-yuan,XIAO Xin-hua. Effect of adiponectin on diabetic macro-angiopathy[J]. Journal of International Pathology and Clinical Medicine, 2008, 28(5): 19-455 | |
| Authors: | DONG Yuan-yuan XIAO Xin-hua |
| Affiliation: | Department of Endocrinology &; Metabolism， jFirst Affiliated Hospital of Nanhua University， Hengyang Hunan 421001, China |
| Abstract: | Adiponectin(APN) is an adipocyte secreting cytokine,which exerts anti-inflammatory,anti-diabetic,and anti-atherosclerotic effects via combining with adiponectin receptor-l and 2.The serum adiponectin concentration is similar between type 1 diabetes and normal,but significantly decreased in type 2 diabetes.Cardiovascular complications are evidently augmented in patients with type 2 diabetes.APN levels are significantly lower in cases of cardiovascular diseases combined with type 2 diabetes than those without type 2 diabetes,suggesting that macro-vascular lesions may be related to the lack of APN.Illustrating the mechanism of APN effect on macro-vascular may contribute to provide a new idea that macro-angiopathy is less in type 1 diabetes compare to type 2 diabetes,even though blood glucose fluctuate in a large range. |
| Keywords: | adiopnectin adiopnectin receptor diabetes macrovascular |
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