| HPLC测定罗红霉素软胶囊的溶出度 |
| |
| 引用本文： | 张传学,王建. HPLC测定罗红霉素软胶囊的溶出度[J]. 中国现代应用药学, 2013, 30(3): 303-306 |
| |
| 作者姓名： | 张传学 王建 |
| |
| 作者单位： | 浙江省武义县第一人民医院药剂科，浙江 武义 321200;浙江省食品药品检验研究院，杭州 310004 |
| |
| 基金项目： | 国家药典委员会国家药品标准提高研究项目(国药典化发[2010]84号) |
| |
| 摘 要： | 目的 采用HPLC测定罗红霉素软胶囊的溶出度。方法 以醋酸盐缓冲液(pH 5.5)为溶出介质，桨法，转速为100 r·min-1，60 min时取样，取样后采用HPLC测定。结果 罗红霉素在0.02~ 0.2 mg·mL-1内呈良好的线性关系(r=0.999 9)，罗红霉素软胶囊的平均回收率为100.1％(RSD=0.6%)，溶出液稳定，3批软胶囊在60 min时平均溶出度均在75%以上并且有较好的均一性。结论 该法可用于罗红霉素软胶囊溶出度的测定。
|
| 关 键 词： | 罗红霉素软胶囊；溶出度；高效液相色谱法 |
| 收稿时间： | 2012-07-26 |
| 修稿时间： | 2012-12-10 |
Determination of the Dissolution of Roxithromycin Soft Capsules by HPLC |
| |
| ZHANG Chuanxue and WANG Jian. Determination of the Dissolution of Roxithromycin Soft Capsules by HPLC[J]. The Chinese Journal of Modern Applied Pharmacy, 2013, 30(3): 303-306 |
| |
| Authors: | ZHANG Chuanxue and WANG Jian |
| |
| Abstract: | OBJECTIVE To determine the dissolution of roxithromycin soft capsules by HPLC. METHODS The dissolution medium was acetate buffer (pH 5.5). Apparatus 2 was used with 100 r·min-1. The dissolution medium was taken and analyzed by HPLC at 60 minutes. RESULTS It showed that the standard curve was linear in the range of 0.02-0.2 mg·mL-1(r=0.999 9). The average recovery was 100.1%(RSD=0.6%) for roxithromycin soft capsules. The dissolutions of soft capsules from three batches were over 75%. CONCLUSION The established method can be used for determination of roxithromycin soft capsules dissolution. |
| |
| Keywords: | roxithromycin soft capsules dissolution HPLC |
|
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
|
点击此处可从《中国现代应用药学》下载全文 |
