| 山茛菪碱(654-2)的抗炎症作用 |
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| 引用本文： | 陈祥银,严仪昭,曾卫东,西品香.山茛菪碱(654-2)的抗炎症作用[J].中国医学科学院学报,1987(1). |
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| 作者姓名： | 陈祥银 严仪昭 曾卫东 西品香 |
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| 作者单位： | 中国医学科学院基础医学研究所病理生理室 北京
(陈祥银，严仪昭)，江西医院 进修医师
(曾卫东)，中国医学科学院基础医学研究所病理生理室 北京(西品香) |
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| 摘 要： | 山莨菪碱(654-2)对二氧化硫吸入所致大鼠急性气管炎,角叉菜胶所致大鼠脚爪水肿,油酸所致大鼠急性肺损伤及博莱霉素A5所致肺纤维化均有保护作用。阻断组胺作用及抑制溶酶体酶的释放,可能是654-2抗炎症作用的部分环节。
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| 关 键 词： | 山莨菪碱 炎症 组胺 溶酶体 |
Inhibitory Effect of Anisodamine(654-2) on Inflammatory Reaction |
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| Chen Xiangyin,Yan Yizhao,Zeng Weidong and Xi Pinxiang.Inhibitory Effect of Anisodamine(654-2) on Inflammatory Reaction[J].Acta Academiae Medicinae Sinicae,1987(1). |
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| Authors: | Chen Xiangyin Yan Yizhao Zeng Weidong and Xi Pinxiang |
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| Abstract: | Effects of anisodamine (654-2) on inflammatory reaction were investigated. Results showed that anisodamine could inhibit SO2-induced acute bronchitis in rats, carrageenen-induced rat paw edema, oleic acid-induced rat lung injury, and bleomycin A5-induced mouse lung fibrosis. It is suggested that inhibition of histamine pharmacological effect and lysosomal enzyme release may be responsible for antiinflammatory effect of anisodamine. |
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| Keywords: | anisodamine inflammation histamine lysosome |
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