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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles
Authors:Reka Agnes Haraszti  Rachael Miller  Marie-Cecile Didiot  Annabelle Biscans  Julia F. Alterman  Matthew R. Hassler  Loic Roux  Dimas Echeverria  Ellen Sapp  Marian DiFiglia  Neil Aronin  Anastasia Khvorova
Affiliation:1. RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA;2. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA;3. Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA;4. Mass General Institute for Neurodegenerative Disease, Boston, MA, USA
Abstract:
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  • Keywords:extracellular vesicles  siRNA  oligonucleotides  nanovesicles  chemical modification  RNA therapy  exosomes
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