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Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice
Authors:Christopher A. Pennell  Jessie L. Barnum  Cameron S. McDonald-Hyman  Angela Panoskaltsis-Mortari  Megan J. Riddle  Zhengming Xiong  Michael Loschi  Govindarajan Thangavelu  Heather M. Campbell  Meghan D. Storlie  Yosef Refaeli  Scott N. Furlan  Michael C. Jensen  Leslie S. Kean  Jeffrey S. Miller  Jakub Tolar  Mark J. Osborn  Bruce R. Blazar
Affiliation:1. Department of Laboratory Medicine and Pathology, Masonic Cancer Center, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA;2. Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA;3. Stem Cell Institute, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA;4. Division of Hematology and Oncology, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA;5. Department of Dermatology, University of Colorado, Aurora, CO 80045, USA;6. Division of Pediatric Hematology-Oncology, Department of Pediatrics, The Ben Towne Center for Childhood Cancer, The Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98101, USA;7. Division of Hematology, Oncology, and Transplantation, Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Abstract:
Keywords:B cell aplasia  CAR T cell  CD19  cytokine release syndrome  mouse model  neurologic adverse events  toxicity
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