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Age-dependent alteration in muscle regeneration: the critical role of tissue niche |
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| Authors: | Laura Barberi Bianca Maria Scicchitano Manuela De Rossi Anne Bigot Stephanie Duguez Aurore Wielgosik Claire Stewart Jamie McPhee Maria Conte Marco Narici Claudio Franceschi Vincent Mouly Gillian Butler-Browne Antonio Musarò |
| Affiliation: | 1. Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Rome, Italy 2. Institute of Histology and Embryology, Catholic University School of Medicine, Rome, Italy 3. Thérapie des Maladies du Muscle Strié, Institut de Myologie UMRS 974-UPMC University, Paris 6, U974-Inserm, UMR7215-CNRS, AIM, GH Pitié-Salpétrière, 47 bd de L’H?pital, Paris cedex 13, 75651, Paris, France 4. Research Institute for Sport and Exercise Sciences, School of Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street Campus, Liverpool, L3 3AF, UK 5. Institute for Biomedical Research into Human Movement and Health Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M1 5GD, UK 6. Department of Experimental Diagnostic and Specialty Medicine and Interdepartmental Centre “L. Galvani” (CIG), University of Bologna, via S. Giacomo 12, 40126, Bologna, Italy 7. Division of Clinical Physiology, School of Graduate Entry to Medicine, Derby Royal Hospital, University of Nottingham, Uttoxeter Rd, Derby, DE22 3DT, UK 8. Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy 9. Sapienza University of Rome-Unit of Histology and Medical Embryology, Rome, Italy |
| Abstract: | Although adult skeletal muscle is composed of fully differentiated fibers, it retains the capacity to regenerate in response to injury and to modify its contractile and metabolic properties in response to changing demands. The major role in the growth, remodeling and regeneration is played by satellite cells, a quiescent population of myogenic precursor cells that reside between the basal lamina and plasmalemma and that are rapidly activated in response to appropriate stimuli. However, in pathologic conditions or during aging, the complete regenerative program can be precluded by fibrotic tissue formation and resulting in functional impairment of the skeletal muscle. Our study, along with other studies, demonstrated that although the regenerative program can also be impaired by the limited proliferative capacity of satellite cells, this limit is not reached during normal aging, and it is more likely that the restricted muscle repair program in aging is presumably due to missing signals that usually render the damaged muscle a permissive environment for regenerative activity. |
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