内毒素对实验性肝功能不全的作用

本文对大肠杆菌内毒素(LPS)在实验性早期和晚期肝硬化中的致病作用进行了研究。实验结果表明,LPS有加剧肝纤维增生与抑度肝纤维重吸收的作用,并使肝细胞损伤明显加重。LPS可诱发和加剧肝功能不全的发生与发展,即肾功能不全、肝性脑病、胆红素代谢异常、凝血功能紊乱和促进钠、水滞留与腹水生成。由此可见,内毒素血症是肝硬化与肝功能不全发生与发展的重要因素。

The effect of endotoxin on experimental hepatic insufficiency

The effect of E. coli endotoxin (LPS) on early and advanced experimental cirrhosis have been studied. Results indicate that LPS has exhibited a significant promoting effect on liver damage and fibrosis, exerted inhibitory effect on colcollagen resorption. The rats with early and advanced cirrhosis were administered with LPS. Their parenchymal cells of the liver had more prominent lesion than those of the controls. The experiments demgnstrated that the hepatic renal dysfunction, hepatic encephalopathy, hilirubin metabolic disorder of the cirrhotic rats were induced and aggravated by LPS. Thus it proved that LPS is an importent pathogenic factor in the development and progress of hepatie insufficiency.