Influence of enkephalin on K+-evoked efflux of putative neurotransmitters in rat brain |
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| Authors: | N. Subramanian P. Mitznegg W. Sprügel W. Domschke S. Domschke E. Wünsch L. Demling |
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| Affiliation: | (1) Pharmakologisches Institut, Universität Erlangen-Nürnberg, Universitätsstrasse 22, D-8520 Erlangen, Federal Republic of Germany;(2) Medizinische Klinik, Universität Erlangen-Nürnberg, D-8520 Erlangen, Federal Republic of Germany;(3) Max Planck Institut für Biochemie, D-8000 München, Federal Republic of Germany |
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| Abstract: | ![]()
Summary In rat brain slices preincubated with various radiolabelled putative neurotransmitters, methionine-enkephalin diminished the potassium-evoked release of dopamine and acetylcholine. The effect was antagonised by naloxone. The potassium-induced efflux of three other neurotransmitters, histamine, 5-hydroxytryptamine and  -aminobutyric acid, were unaffected by methionine-enkephalin. A probable physiological function for the endogenous ligands in specifically affecting the catecholaminergic and cholinergic transmission is suggested. |
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| Keywords: | Enkephalin Naloxone Dopamine release Acetylcholine release Neurotransmitter release |
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