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Effects of ambient particulate matter on vascular tissue: a review |
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| Authors: | Kristina Shkirkova Krista Lamorie-Foote Michelle Connor Arati Patel Giuseppe Barisano Hans Baertsch |
| Affiliation: | 1. Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, USA Kristina.shkirkova@usc.edu!["ORCID]({"type":"image","src":"/templates/jsp/images/orcid.png"} "\"ORCID") https://orcid.org/0000-0002-9288-4258;3. Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, USA;4. Department of Neurosurgery, Keck School of Medicine, University of Southern California , Los Angeles, USA;5. Department of Neurosurgery, Keck School of Medicine, University of Southern California , Los Angeles, USA https://orcid.org/0000-0002-2300-0391;6. Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, USA |
| Abstract: | ABSTRACT Fine and ultra-fine particulate matter (PM) are major constituents of urban air pollution and recognized risk factors for cardiovascular diseases. This review examined the effects of PM exposure on vascular tissue. Specific mechanisms by which PM affects the vasculature include inflammation, oxidative stress, actions on vascular tone and vasomotor responses, as well as atherosclerotic plaque formation. Further, there appears to be a greater PM exposure effect on susceptible individuals with pre-existing cardiovascular conditions. |
| Keywords: | Particulate matter air pollution vascular tissue endothelial cells inflammation vascular tone oxidative stress atherosclerotic plaque |