急性冠状动脉综合征患者血清超敏C-反应蛋白水平变化及其影响因素

目的 探讨急性冠状动脉综合征(ACS)患者血清超敏C-反应蛋白(hsCRP)和心肌肌钙蛋白I(cTnI)变化及其影响因素.方法 ①采用化学发光免疫分析法检测50例ACS患者、20例OMI患者和20名健康人的hsCRP和cTnI含量.②以hsCRP为因变量,以年龄、性别、高血压史、糖尿病史、吸烟史、cTnI、甘油三酯(TG)、胆固醇(CHO)、载脂蛋白A(APOA)、载脂蛋白B(APOB)、血糖(GLU)、高密度脂蛋白胆固醇(HDL-C)、尿酸(URI)为自变量进行多元逐步回归分析.结果 ①ACS组的hsCRP、cTnI均高于OMI组和对照组(P＜0.05);OMI组的hsCRP、cTnI水平与对照组相比有升高趋势,但差别无统计学意义(P＞0.05).②以hsCRP作为因变量的多元逐步回归方程式为:hsCRP=-3.362 0.02446X7 1.097X9(X7为cTnI,X9为CHO,X7、X9显著性均为P＜0.01).结论 ACS患者血清hsCRP、cTnI水平明显升高;血清hsCRP水平和cTnI、CHO呈正相关.

Changes and relevant influence factors of high sensitivity C-reactive protein of patients with acute coronary syndrome

Objective To investigate the relationship between serum high sensitivity C-reactive protein (hsCRP),Cardiac Troponin I(cTnI) and the incidence of major cardiac events of the patients with acute coronary syndrome(ACS), the levels of serum hsCRP and cTnI were detected 8-12 h after acute chest pain in the patients with ACS. Methods (1)hsCRP,cTnI were measured by way of a chemiluminescence immunoassay. (2)The affecting factors of age,gender,history of hypertension,diabetes mellitus,history of smoking,cTnI,TG,CHO,APOA,APOB,GLU,HDL-C and URI were analynized in a Multiple Stepwise Regression model with the hsCRP as the dependent variable. Results (1)Serum hsCRP and cTnI were higher in the ACS group than that in the OMI and Control group(P<0.05=. The hsCRP and cTnI in the OMI group were higher than that in the control group,but no statistical significance(P>0.05). (2)The Multiple Stepwise Regression equation was: hsCRP=-3.362+0.02446X7+1.097X9(X7:cTnI,X9:CHO,P<0.01=.It suggested that hsCRP is positively associated with cTnI and CHO. Conclusion Serum hsCRP,cTnI are significantly higher in the ACS group than those in the OMI and control group(P<0.05=. Serum hsCRP of the ACS group is positively related with cTnI and CHO.