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Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats |
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| Authors: | Ertugrul Uzar Harun Alp Mehmet Ugur Cevik Ugur F?rat Osman Evliyaoglu Adnan Tufek Yasar Altun |
| Affiliation: | 1. Department of Neurology, Faculty of Medicine, Dicle University School of Medicine, 21280, Diyarbak?r, Turkey 2. Department of Pharmacology, Faculty of Veterinary, Dicle University, Diyarbak?r, Turkey 3. Department of Pathology, Faculty of Medicine, Dicle University, Diyarbak?r, Turkey 4. Department of Biochemistry, Faculty of Medicine, Dicle University, Diyarbak?r, Turkey 5. Department of Anesthesiology, Faculty of Medicine, Dicle University, Diyarbak?r, Turkey 6. Department of Neurology, Siirt State Hospital, Siirt, Turkey |
| Abstract: | The aim of this study was to investigate the possible effects of ellagic acid in brain and sciatic nerve tissues of diabetic rats. Also, the impact of ellagic acid on catalase and paraoxonase (PON-1) activities, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and nitric oxide (NO) were examined. The rats were randomly divided into four groups, with eight rats each: Normal controls (not diabetic), only ellagic acid treated (ellagic acid controls, not diabetic), Diabetic controls (streptozotocin, diabetic), ellagic acid-treated diabetic (streptozotocin?+?ellagic acid). After a 4?week experiment, rats were sacrificed, and biomarkers for oxidative stress in the brain and sciatic nerve tissues of the rats were measured. There was significant depletion in the PON-1, catalase, and TAS levels in the brain and sciatic nerve tissues compared to the control groups (for both parameters, p?p?p?p? |
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