代谢综合征高危人群血脂与胰岛功能的关系

目的探讨代谢综合征高危人群血脂与胰岛功能的关系。方法收集符合代谢综合征高危因素且既往无糖尿病史的体检人员249名,并对入选者进行问卷调查、体格检查、血脂及代谢相关指标的测定,同时行口服糖耐量实验(OGTT)。结果该人群中甘油三酯(TG)与餐后2小时血糖(PBG)、空腹胰岛素(FINS)、餐后2小时胰岛素(PINS)、空腹C肽(FCP)、餐后2小时C肽(PCP)和HOMA胰岛素抵抗指数(HOMA-IR)呈正相关(P0.05);总胆固醇水平(TC)与HOMA-IR和糖化血红蛋白(HbA1c)呈正相关(P0.05);低密度脂蛋白胆固醇水平(LDL-C)与空腹血糖(FBG)、FINS、FCP、HOMA-IR和HbA1c呈相关(P0.05);高密度脂蛋白胆固醇水平(HDL-C)与FBG、FINS、FCP和HOMA-IR呈负相关(P0.05)。同时相关分析提示该人群中TG水平与腰围、血尿酸(UA)和γ谷氨酰胺(γGGT)呈正相关(P0.05);TC、LDL-C与γGGT呈正相关(P0.05);HDL-C与腰围、γGGT呈负相关(P0.05)。血脂水平与血压并无明显相关性。结论代谢综合征高危人群中血脂水平与胰岛功能密切相关,并与胰岛素抵抗有关,提示积极的降脂治疗有利于保护胰岛功能,防治代谢综合征及其并发症的进一步发生发展。

The relationship between lipid levels and islet function in high risk of metabolic syndrome people

Objective To discuss the relationship between blood lipid levels and islet function in high risk of metabolic syndrome people.Methods Fasting blood were obtained from 249 objects who were diagnosed as high risk of metabolic syndrome without diabetes in the health examinations.Questionnaires,physical examinations,blood lipid,metabolic indicators and oral glucose tolerance test（OGTT） were performed on these objects.Results In this group,triglyceride（TG） was positively correlated with 2-hour postprandial blood glucose（PBG）,fasting insulin（FINS）,2-hour postprandial insulin（PINS）,fasting C peptide（FCP）,2-hour postprandial C peptide（PCP） and HOMA insulin resistance index（HOMA-IR）（P〈0.05）;total cholesterol（TC） was positively correlated with HOMA-IR and glycated hemoglobin（HbA1c）（P〈0.05）;low-density lipoprotein cholesterol（LDL-C） was positively correlated with fasting blood glucose（FBG）,FINS,FCP,HOMA-IR and HbA1c（P〈0.05）;high-density lipoprotein cholesterol（HDL-C） was negatively correlation with FBG,FINS,FCP and HOMA-IR（P〈0.05）.Correlation analysis also showed that TG was positively correlated with waist circumference,serum uric acid（UA） and γ-glutamine（γGGT）（P〈0.05）;TC and LDL-C was positively correlated withγGGT;HDL-C was negatively correlation with waist circumference andγGGT（P〈0.05）.There was no significant correlation between blood lipid levels and blood pressure.Conclusion Blood lipid levels are closely related with islet function in people with high risk of metabolic syndrome,and are associated with insulin resistance,which suggest lipid-lowering therapy is conducive to the protection of islet function,and prevent the development of metabolic syndrome and further complications.