Anti-hepatitis C virus antibodies and hepatitis C virus viraemia in haemodialysis patients |
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| Authors: | Piciotto, A. Varagona, G. Gurreri, G. Fiorini, F. Sofia, A. Coviello, D. A. Bonanni, P. Icardi, G. C. Valle, F. Celle, G. |
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| Affiliation: | 1Department of Internal Medicine, University of Genoa Italy 2Gastroenterology and Nephrology Units, University of Genoa Italy 3Institute of Biology and Genetics, University of Genoa Italy 4Institute of Hygiene and Preventive Medicine, University of Genoa Italy |
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| Abstract: | ![]()
Sera from 82 haemodialysis patients were tested for anti-HCV,HCV-RNA, and HBsAg. Alanine aminotransferase (ALT) activitywas monitored weekly for 2 months. Anti-HCV was positive in31 patients (37.8%), showing different single-peptide patterns.HCV-RNA was detected in 26 anti-HCV-positive patients (84%)and also in two of 21 anti-HCV-negative patients. Twenty-seven(87%) of the 31 anti-HCV-positive patients had persistentlynormal ALT values; 22 of these patients were HCV-RNA positive.The four patients with elevated ALT values had HCV viraemia.HBsAg was positive in nine anti-HCV-negative patients. The closecorrelation between HCV viraemia and HCV status, independentlyof ALT values, requires that anti-HCV dialysis patients mustbe considered potentially infective and dialysed with reservedmachines and/or in separate shifts. |
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| Keywords: | anti-HCV ALT haemodialysis patients HBsAg HCV-RNA PCR |
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