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| 红细胞生成素对血透患者自然杀伤细胞活性的影响 | |
| 引用本文： | 蒋建平 张训. 红细胞生成素对血透患者自然杀伤细胞活性的影响[J]. 中华肾脏病杂志, 1997, 13(2): 70-72 |
| 作者姓名： | 蒋建平 张训 |
| 作者单位： | 广州第一军医大学南方医院肾内科 510515(蒋建平，张训)，广州第一军医大学南方医院肾内科 510515(候凡凡) |
| 摘 要： | 目的 探讨血透患者自然杀伤细胞(NK)活性与贫血之间的关系。方法 采用LDH释放法,对12例血透接受重组人红细胞生成素(rHuEPO)治疗前后血红蛋白(Hb)水平和NK活性进行观察。结果 经rHuEPO治疗后,患者Hb和NK活性均有明显提高,但rHuEPO对NK细胞并无刺激作用,而红细胞对NK细胞活性有明显的增强作用。结论 血透患者的NK细胞活性低下与贫血有关,rHuEPO提高NK细胞活性的作用是通过改善贫血而非rHuEPO的直接作用。 |
| 关 键 词： | 红细胞生成素 贫血 自然杀伤细胞活性 |
The effect of recombinant human erythropoietin(rHuEPO) on NK cell cytotoxicity in hemodialysis patients |
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| Jiang Jianping,Zhang Xun,Hou Fanfan. The effect of recombinant human erythropoietin(rHuEPO) on NK cell cytotoxicity in hemodialysis patients[J]. Chinese Journal of Nephrology, 1997, 13(2): 70-72 | |
| Authors: | Jiang Jianping Zhang Xun Hou Fanfan |
| Affiliation: | Jiang Jianping,Zhang Xun,Hou Fanfan,Department of Nephrology,Nanfang Hospital,Guangzhou 510515 |
| Abstract: | Objective To evaluate the relationship between NK cytotoxicity and anemia in uremia. Methods The effect of rHuEPO on natural killer (NK) cell cytotoxic activity was studied in 12 hemodialysis(HD) patients. Results The levels of hemoglobin (Hb) and NK cell activity were significantly lower in HID patients than that in healthy controls. After two months of the treatment with rHuEPO, the levels of Hb in these patients rose significantly with a parallel rise in NK cell activity. NK cell activity was not increased when they were incubated with rHuEOP but was increased with red blcxxl cells. Conclusion Improved NK cell cytotoxicity in HD patients after treatment with rHuEPO was achieved through the rise in R15C rather than through rHuEPO itself. |
| Keywords: | rHuEPO Anemia Natural killer cell cytotoxicity |
| 本文献已被 CNKI 维普 等数据库收录！ | |