灯盏花素注射液对慢性肺源性心脏病失代偿期血管内皮功能及心功能的影响

目的探讨灯盏花素注射液对慢性肺源性心脏病(肺心病)患者失代偿期血管内皮功能及血流动力学的影响。方法将84例患者随机分为治疗组46例和对照组38例。对照组选用敏感抗生素,常规止咳、祛痰、平喘,心功能不全者加用地高辛或利尿剂;治疗组在对照组治疗的基础上加用灯盏花素注射液50mg,1次/d。两组疗程均为20d。结果①两组患者治疗后血清ET、NO水平较治疗前明显升高,差异有统计学意义(P0.01);治疗组血清sVCAM-1、sICAM-1水平较治疗前明显下降,差异有统计学意义(P0.01);治疗后治疗组血清ET、sVCAM-1、sICAM-1、NO水平与对照组比较,差异有统计学意义(P0.01);治疗后治疗组心排血量(CO)和心脏指数(CI)均较对照组有明显改善(P0.01)。治疗后两组临床心功能改善情况比较,差异亦有统计学意义(P0.05)。结论灯盏花素能显著改变慢性肺心病患者的血管内皮功能,明显改善血液流变学,提高机体免疫功能,改善心功能,提高失代偿期临床疗效。

Impacts of Breviscapine Injection on Vascular Endothelia Function and Heart Function in Chronic Cor Pulmonale Decompensation

Objective To probe into the impacts of breviscapine injection on vascular endothelia function and hemodynamics in chronic cor pulmonale decompensation（pulmonary heart disease）.Methods 84 cases were divided randomly into treatment group（46 cases）and control group（38 cases）.In control group,sensitive antibiotic were optioned for stopping cough,removing sputum and relieving asthma conventionally.For the cases with heart dysfunction,digoxin or diuretics were supplemented.In treatment group,on the basis of the treatment as control group,breviscapine injection 50mg,qd,was supplemented.The course of treatment in two groups was 20 days.Results After treatment,serum ET and NO levels increased apparently as compared with those before treatment in both groups,indicating statistical significant difference（P0.01）.In treatment group,the serum sVCAM-1 and sICAM-1 levels decreased apparently as compared with those before treatment,indicating statistical significant difference（P0.01）.After treatment,in treatment group,serum ET,sVCAM-1,sICAM-1 and NO levels were different significantly in statistics as compared with those in control group（P0.01）.After treatment,in treatment group,cardiac output（CO）and cardiac index（CI）were improved apparently as compared with control group（P0.01）.After treatment,there was no significant difference in clinical heart function improvement between two groups in statistics（P0.05）.Conclusion Breviscapine injection can improve vascular endothelial function significantly,and hemorheologic indexes apparently,as well as body immune function,heart function and clinical efficacy in decompensation.