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Pituitary Adenoma with Peliosis: A Report of Two Cases |
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| Authors: | Safraz Mohammed Luis V. Syro Bernd W. Scheithauer Alberto Abad Humberto Uribe Fabio Rotondo Eva Horvath Michael Cusimano Kalman Kovacs |
| Affiliation: | 1. Division of Neurosurgery, St Michael’s Hospital, 2 Queen Street East, Suite 10 05i, Toronto, ON, Canada, M5C 3G7 2. Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada 8. University of Toronto, Toronto, ON, Canada 3. Department of Neurosurgery, Clinica Medellin and Hospital Pablo Tobon Uribe, Medellin, Colombia 4. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA 5. Laboratorio de Endocrinología, Medellín, Colombia 6. Division of Neurosurgery, Clinica SOMA, Medellín, Colombia 7. Department of Laboratory Medicine, St. Michael’s Hospital, Toronto, ON, Canada |
| Abstract: | Peliosis is characterised by multiple blood-filled lakes or cavities within parenchymatous organs. Typically found in the liver, spleen, bone marrow and lymph nodes, it has also been described in other organs such as lungs, kidneys, parathyroids and pancreas. The mechanism responsible for the development of peliosis remains unknown. (1) A 69 year-old man with a 6-year history of acromegaly underwent transsphenoidal surgery for pituitary adenoma. Morphologic findings demonstrated a plurimorphous plurihormonal pituitary adenoma consisting of somatotrophs, lactotrophs and mammosomatotrophs. The tumor contained several blood-filled cavities characteristic of peliosis. (2) A 61-year-old man with a prolactin-producing pituitary adenoma who underwent transsphenoidal surgery. In the tumor, peliosis was noted. Peliosis in a pituitary adenoma is an intriguing finding. The question arises whether it represents vasculogenic mimicry. |
| Keywords: | oncology pathology peliosis pituitary pituitary neoplasm vasculogenic mimicry |
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