Toll样受体调节中性粒细胞免疫作用的研究进展

Toll样受体（TLR）是固有免疫系统中特异的I型跨膜受体及病原模式识别受体。TLR能特异地识别病原体相关分子模式（PAMP）,构成机体抵御病原微生物的第一道防线,因而在固有免疫系统中发挥重要作用,而且TLR还能调节适应性免疫,是连接固有免疫和适应性免疫的桥梁。中性粒细胞（PMN）是机体最重要的炎性细胞,在固有免疫中扮演着十分重要的角色,对炎症的发生、发展及转归起了关键的作用。作为重要受体的TLR能诱导PMN的生存与活化,在急性炎症反应、细胞信号转导和细胞凋亡中起着重要作用。

The study progress in the regulatory effects of Toll-like receptor on the immune roles of neutrophils

Toll-like receptor (TLR) is a specific type I transmembrane receptor and pathogen pattern recognition receptors of the innate immune system.TLR can specifically identify pathogen-associated molecular pattern (PAMP).The recognition of TLR to PAMP constitutes the first line of body defending against pathogenic mierolmes,and plays a major role in the innate immune system.This process also regulates acquired immune.Therefore,TIR is a bridge between innate immunity and acquired immunity.Polymorphonuclear neutrophils (PMNs) are important inflammatory cells that play a key role in innate immune and are related to the occurrence,development and resolution of inflammation.As an important receptor,TLR is able to induce the survival and activation of neutrophils,by which it plays a marked role in the acute inflammatory response,cellular signal transduction and apoptosis of neutrophiis.