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| 表皮干细胞与表皮肿瘤 | |
| 引用本文： | 卜璋于,蔡绥勍. 表皮干细胞与表皮肿瘤[J]. 国际皮肤性病学杂志, 2007, 33(3): 145-147 |
| 作者姓名： | 卜璋于 蔡绥勍 |
| 作者单位： | 310009,杭州,浙江大学医学院附属第二医院皮肤科 |
| 基金项目： | 浙江省科技计划项目（2005C33029） |
| 摘 要： | 表皮干细胞具有无限增殖及多向分化的特性，其子代细胞可以形成角质形成细胞、毛囊、皮脂腺的分化细胞。肿瘤一般起源于单个发生癌性突变的细胞，表皮干细胞很可能是各种类型表皮肿瘤发生的主要靶细胞，分化细胞则能通过影响肿瘤干细胞的克隆扩增，对肿瘤的发生起重要作用。 |
| 关 键 词： | 表皮 干细胞 肿瘤 |
| 修稿时间： | 2006-07-14 |
Epidermal stem cells and epidermal tumors |
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| BU Zhang-yu,CAI Sui-qing. Epidermal stem cells and epidermal tumors[J]. International Journal of Dermatology and Venereology, 2007, 33(3): 145-147 | |
| Authors: | BU Zhang-yu CAI Sui-qing |
| Affiliation: | Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China |
| Abstract: | Epidermal stem cells have the ability to perpetuate themselves through selfrenewal and the potential of multilineage differentiation. The differentiated cells originated from them could form interfollicular epidermis (IFE), hair follicles and sebaceous glands. Since most tumors are derived from a single cell with oncogenic mutations, multipotent epidermal stem cells are likely to be the main target of various epidermal tumors. Differentiated cells may contribute to the development of tumors by regulating the clonal expansion of tumor stem cells. |
| Keywords: | Epidermis Stem cell Neoplasms |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |