脑卒中后抑郁对患者免疫功能的影响

目的了解脑卒中后抑郁患者的机体免疫功能状态。方法收集并分析南通大学附属南通第三医院2012年10月~2015年10月住院治疗的首次脑卒中患者90例[脑卒中后抑郁(PSD)、单纯脑卒中各45例],同时收集抑郁症、健康对照各30例,分析外周血T细胞亚群、免疫球蛋白及补体表达水平。结果无论PSD组还是抑郁症组T细胞亚群均不同程度地低于健康对照组(P0.05),PSD组更为低下,与抑郁症组比较存在统计学差异(P0.05)。无论PSD组还是抑郁症组IgG、IgA、IgM水平均较健康对照组下降,组内比较PSD组较抑郁症组更为低下(P0.05),单纯脑卒中组和健康对照组IgG、IgA、IgM水平均处于正常范围,但单纯脑卒中组IGg水平较健康对照组低下(P0.05);PSD组与抑郁症组补体C3水平均有不同程度地升高,PSD组较抑郁症组升高更为明显(P0.05),而4组补体C4水平均处于正常水平,组间比较无统计学差异(P0.05)。结论脑卒中后抑郁人群机体免疫功能存在不同程度的受损,可随病情持续进展,需加强动态监测,对于免疫力明显低下人群,可早期干预,阻止病情持续进展。

Immune function in patients with post stroke depression

ObjectiveTo investigate the immune function of post stroke depression(PSD)patients.Methods 90 stroke patients(half of which with depression)admitted in third people's Hospital from October 2012 to October 2015 were collected and analyzed. At the meantime, 30 depression patients and 30 healthy people were collected as control groups.Then analyzed expression of T lymphocyte subsets, immunoglobulin and complement in peripheral blood of all the people.Results The T lymphocyte subsets in both PSD group and depression group were significantly lower than those in healthy group(P<0.05)and had statistical significance.Obviously, the PSD group was more lower. Compared to healthy group, IgG,IgA and IgM in the PSD group and depression group were lower.PSD group was even lower than the depression group(P<0.05).IgG,IgA and IgM levels in stroke group and healthy group were in the normal range, but the stroke group was lower compared to the healthy group(P<0.05). Complement C3 level in both PSD group and depression group increased,while PSD group was higher(P<0.05).However,the levels of four groups were in normal range,and there was nostatistical significance among the four groups(P>0.05).Conclusion Patients with PSD have immune function impaired to some extent,and may become worser with the disease progress. We need to strengthen the dynamic monitoring of related immune indexes,and do something for PSD patients with lower immunity to interpose early and prevent the progression of the disease.