Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder |
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| Authors: | Norma O. Uribe-Uribe Aura Matilde Jimenez-Gardu?o Donald E. Henson Jorge Albores-Saavedra |
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| Affiliation: | 1. Centre for Integrative Biology (CIBIO), Laboratory of Molecular and Cellular Neurobiology, University of Trento, Via Sommarive 9, 38123 Trento, Italy;2. Istituto di Biofisica, Unità di Trento, Consiglio Nazionale delle Ricerche (IBF-CNR), Via alla Cascata 56/C 18, 38123 Trento, Italy;3. Istituto dei Materiali per l''Elettronica ed il Magnetismo, Consiglio Nazionale delle Ricerche (IMEM-CNR), Sede di Trento, Via alla Cascata 56/C, 38123 Trento, Italy;4. Department of Industrial Engineering, University of Trento, via Sommarive 14, 38123 Trento, Italy;5. Fondazione Bruno Kessler (FBK), CMM-LaBSSAH, Via Sommarive 18, 38123 Trento, Italy;6. Fondazione Bruno Kessler (FBK), CMM-FMPS, Via Sommarive 18, 38123 Trento, Italy;7. Istituto Officina dei Materiali del CNR (CNR-IOM), Unità di Perugia, c/o Dipartimento di Fisica e Geologia, Via Pascoli, 06123 Perugia, Italy;8. Istituto dei Materiali per l''Elettronica ed il Magnetismo, Consiglio Nazionale delle Ricerche (IMEM-CNR), Parco Area delle Scienze 37/A, 43124 Parma, Italy |
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| Abstract: | ![]()
A small number of patients with carcinoma of the gallbladder can present with a variety of paraneoplastic syndromes, including the Cushing syndrome, hypercalcemia, acanthosis nigricans, bullous pemphigoid, dermatomyositis, and the Leser-Trélat sign. We report on what appears to be the first case of a patient, a 48-year-old woman, with anti-Hu paraneoplastic sensory neuropathy and small cell carcinoma of the gallbladder. The patient's neurologic symptoms preceded the diagnosis of small cell carcinoma by 11 months. These symptoms improved after surgical removal of the tumor and chemotherapy. The small cell carcinoma was relatively small and was not associated with gallstones. In spite of the small size of the tumor, it metastasized to a celiac lymph node and probably to the liver. Anti-Hu paraneoplastic sensory neuropathy should be added to the list of paraneoplastic syndromes associated with small cell carcinoma of the gallbladder. |
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