Dissociation between renal prostaglandin E2 and renin release. Effects of glucagon,dopamine and cyclic AMP in dogs

VIKSE, A., BUGGE, J., DAHL, E. & KIIL, F. 1985. Dissociation between renal prostaglandin E₂ and renin release. Effects of glucagon, dopamine and cyclic AMP in dogs. Acta Physiol Scand 125 , 619–626. Received 14 March 1985, accepted 10 May 1985. ISSN 0001–6772. University of Oslo, Institute for Experimental Medical Research, Ullevaal Hospital, Norway. To examine the relationship between prostaglandin E₂ (PGE₂) and renin release, glucagon, dopamine and dibutyryl cyclic AMP (DB-cAMP) were infused into dog kidneys during autoregulatory dilation of preglomerular vessels. Autoregulatory vasodilation, which enhances PGE₂ and renin release, was induced by renal arterial constriction or ureteral occlusion. Glucagon infusion increased both PGE₂ and renin release during autoregulatory vasodilation, and renin release was almost abolished after inhibiting PGE₂ release by indomethacin. In contrast, dopamine and DB-cAMP infused during autoregulatory vasodilation increased renin release without significantly changing PGE₂ release. Stimulation of renin release was not dependent on vasodilatory effects, which for all drugs were greatly diminished during autoregulatory vasodilation. Hence, glucagon stimulates both PGE₂ and renin release. Most of the increase in renin release during glucagon infusion is prostaglandin-dependent since indomethacin greatly reduced the stimulatory effect. In contrast, dopamine and DB-cAMP stimulate renin release without increasing PGE₂ release as previously found for β-adrenergic stimulation.