| 双氢青蒿素诱导前列腺癌PC-3细胞凋亡 |
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| 引用本文： | 李庆春,高小玲,邹聪,李剑,罗子国. 双氢青蒿素诱导前列腺癌PC-3细胞凋亡[J]. 肿瘤防治研究, 2010, 37(3): 312-314. DOI: 10.3971/j.issn.1000-8578.2010.03.019 |
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| 作者姓名： | 李庆春 高小玲 邹聪 李剑 罗子国 |
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| 作者单位： | 400016重庆医科大学生命科学研究院 |
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| 摘 要： | 目的研究双氢青蒿素（DHA）诱导前列腺癌PC-3细胞凋亡作用，并观察其形态学变化。方法采用人前列腺癌PC-3细胞建立裸鼠种植瘤模型，20只模型鼠随机分为对照组、溶剂组、DHA大剂量组及小剂量组，经13天干预后，计算抑瘤率；HE染色观察肿瘤组织形态学表现；TUNEL法及Hoechst 33258荧光染色检测凋亡。结果DHA大小剂量组抑瘤率分别为69.221%和63.186%；肿瘤组织内凋亡细胞明显增多；肿瘤细胞凋亡率及凋亡细胞数密度均明显升高（P＜0.05）。结论DHA具有较强的抗肿瘤作用，其作用机制可能与诱导肿瘤细胞凋亡有关。
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| 关 键 词： | 双氢青蒿素 前列腺癌 凋亡 |
| 收稿时间： | 2008-10-08 |
| 修稿时间： | 2009-04-29 |
Apoptosos of Human Prostate Cancer Cell Line PC-3 Induced by Dihydroartemisinin |
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| LI Qing-chun,GAO Xiao-lin,ZOU Cong,LI Jian,LUO Zi-guo. Apoptosos of Human Prostate Cancer Cell Line PC-3 Induced by Dihydroartemisinin[J]. Cancer Research on Prevention and Treatment, 2010, 37(3): 312-314. DOI: 10.3971/j.issn.1000-8578.2010.03.019 |
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| Authors: | LI Qing-chun GAO Xiao-lin ZOU Cong LI Jian LUO Zi-guo |
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| Affiliation: | Institute ofLifeSciences, Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | Objective To study the effects of dihydroartemisinin (DHA) on inducing apoptosis of human prostate cancer PC-3 cells and investigates the morphological changes.Methods Prostate cancer PC-3 cells were transplanted into 20 nude mice to establish the solid tumor mode.These nude mice were randomly divided into 4 groups with 5 mice in each group:control group,solvent group,low dose DHA group and large dose DHA group.The tumor growth inhibition rates were calculated on day 13 after drug administration.Pathomorphi... |
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| Keywords: | Dihydroartemisinin Prostate Cancer Apoptosis |
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