| 凝血因子V基因Leiden 突变和凝血酶原基因G20210A突变与下肢深静脉血栓形成关系的探讨 |
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| 引用本文： | 郭辰虹,郭琼行,龚瑶琴,陈丙玺,常宏,周海斌. 凝血因子V基因Leiden 突变和凝血酶原基因G20210A突变与下肢深静脉血栓形成关系的探讨[J]. 山东大学学报(医学版), 2002, 40(3): 235-237 |
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| 作者姓名： | 郭辰虹 郭琼行 龚瑶琴 陈丙玺 常宏 周海斌 |
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| 作者单位： | 山东大学医学院医学遗传学研究所;山东省立医院普外科 |
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| 摘 要： | 目的 :探讨凝血因子V基因G16 91A突变 (Leiden突变 )和凝血酶原基因G2 0 2 10A突变与下肢深静脉血栓形成的关系。方法 :采用PCR RFLP技术对 86例下肢深静脉血栓形成患者和 10 0例正常对照的健康人群进行凝血因子V基因G16 91A突变和凝血酶原基因G2 0 2 10A突变检测。结果 :86例下肢深静脉血栓形成患者和 10 0例正常对照组中均未检出凝血因子V基因G16 91A突变和凝血酶原基因G2 0 2 10A突变。结论 :凝血因子V基因G16 91A突变和凝血酶原基因G2 0 2 10A突变可能不是中国汉族人群下肢深静脉血栓形成的主要风险因子
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| 关 键 词： | 凝血因子V基因 凝血酶原基因 深静脉血栓形成 |
| 文章编号： | 1671-7554(2002)03-0235-03 |
| 修稿时间： | 2001-04-23 |
The factor V leiden , the G20210A mutation of prothrombin gene and their association with deep vein thrombophilia |
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| GUO Chen-hong,GUO Qiong-xing,GONG Yao-qin,et al. The factor V leiden , the G20210A mutation of prothrombin gene and their association with deep vein thrombophilia[J]. Journal of Shandong University:Health Sciences, 2002, 40(3): 235-237 |
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| Authors: | GUO Chen-hong GUO Qiong-xing GONG Yao-qin et al |
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| Abstract: | Objective:To study the Factor V Leiden , the G20210A mutation of Prothrombin gene and their association with deep vein thrombophilia. Methods: PCR-RFLP analysis was conducted to examine mutation with 86 deep vein thrombophilic patients and 100 health controls. Results: The Factor V Leiden and the mutation of G20210A prothrombin gene were not detectable in any of the patients and controls. Conclusion: The Factor V Leiden and the mutation of G20210A prothrombin gene may not be a significant risk factor for deep venous thrombophilia in Chinese. |
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| Keywords: | Coagulation factor V gene Prothrombin gene Deep vein thrombophilia |
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