补肾生精丸对生精细胞损伤模型大鼠睾丸组织NO,NOS和抗氧化的影响

目的:探讨补肾生精丸治疗男性不育症的作用机制。方法:以腺嘌呤灌胃SD大鼠,诱发生精细胞损伤大鼠模型。测定服用补肾生精丸前后实验动物睾丸组织超氧化物歧化酶(SOD)、一氧化氮合酶(NOS)活性及一氧化氮(NO)、丙二醛(MDA)含量。结果:补肾生精丸可提高生精细胞损伤大鼠睾丸组织SOD活性,降低NOS活性及NO,MDA含量。结论:补肾生精丸对腺嘌呤诱发的大鼠生精细胞损伤具有保护作用,其作用与补肾生精丸能增强SOD活性、降低NOS活性和NO,MDA含量密切相关。

Affection of Bushen Shengjing pill on NO and NOS in testicle and ante-oxidization of rat with spermatogenic cell injury

Objective: Discuss the functional mechanism of treating male infertility with Bushen Shengjing pill(BS).Method: Fill the SD rat with adenine so as to injure the germ cell which will produce the model rat with kidney yang deficiency.Measure the activity of SOD and NOS,the amount of NO and MDA in the testicle.Result: BS can promote the activity of SOD,reduce the activity of NOS and the amount of NO and MDA.Conclusion: BS has the function of protecting the germ cell which is closely related to the function that the pill can promote the activity of SOD,reduce the activity of NOS and the amount of NO and MDA.