红霉素发酵液中污染细菌的分离与鉴定及其对红霉素发酵的影响

作者从红霉素发酵污染液中分离出了４５株污染细菌，对其进行了分类鉴定，其中有３９株属于芽孢杆菌属的８个种，有５株属于微球菌属，１株为无芽孢的杆菌。利用芽孢杆菌属８个种的污染细菌进行了人为模拟污染的红霉素发酵试验，其结果表明：其中凝结芽孢杆菌、枯草芽孢杆菌、地衣芽孢杆菌、蜡状芽孢杆菌、坚强芽孢杆菌等５种芽孢杆菌对红霉素发酵有显著影响；其危害极大。短芽孢杆菌对红霉素发酵影响不大，而巨大芽孢杆菌和短小孢杆

THE IDENTIFICATION OF CONTAMINATING BACTERIA ISOLATED FROM THE FERMENTATION BROTH OF ERYTHROMYCIN AND ITS EFFECTS ON FERMETANTIONOF ERYTHROMYCIN

strains of contaminating bacteria were isolated fromthe fermentation broth of Erythromycin and were identified,of all the 45strains there are 39 strains belonging to 8 species of the genus Bacillus,5 strains to the genus Micrococcos and l strain is non-sporeforming rodbacteriurm The fermentation of Erythromycin was artificially contaminated by 39strains of Bacillus.Those of B,coaglans,B.subtillis,B.licheniformis,B. cereus and B. firmus resulted in significantly decrease the productionof Erythromycin;B. brevis had litle influence on the fementation;B.megateriam and B,pumilus increased the pr oduction of Erythrolnycin,theformer increased by 47.8%,the latter by 24%.