| 二氮嗪预处理对心肌再灌注损伤的保护作用 |
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| 引用本文： | 陈天平,张乃菊,蔡鑫.二氮嗪预处理对心肌再灌注损伤的保护作用[J].实用全科医学,2010,8(5):539-541. |
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| 作者姓名： | 陈天平 张乃菊 蔡鑫 |
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| 作者单位： | 陈天平,蔡鑫,CHEN Tian-ping,CAI Xin(安徽省蚌埠医学院第一附属医院心血管科,233004);张乃菊,ZHANG Nai-ju(蚌埠医学院药理系,233000) |
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| 摘 要： | 目的观察二氮嗪预处理对在体大鼠心肌缺血再灌注损伤（IRI）的保护作用。方法健康雄性SD大鼠36只,随机分成4组,每组9只。采用结扎左冠状动脉前降支（LAD）法制备心肌IRI模型。记录缺血再灌注前后不同时间点心功能指标,TTC染色测定心肌梗塞面积,检测血清CK-MB及LDH活性。结果结扎左冠状动脉前降支后：IRI组的CK-MB和LDH显著高于Sham组（P〈0.05）;IPC和DPC组较IRI组显著下降（P〈0.05）。与IRI组比较,IPC组及DPC组梗死面积明显降低（P〈0.05）。缺血30min、再灌注60min、120min时，IRI组、IPC组和DPC组与Sham组比较，±dp／＆max、LVSP、LVEDP有显著的差异（P〈0．05）；IPC组和DPC组与IRI组比较，±dp／dtmax、LVSP差别有统计学意义（ P〈0．05）。结论二氮嗪预处理对在体大鼠缺血再灌注损伤心肌具有保护作用，可降低血清心肌酶含量、减少心肌梗死面积，维护心肌收缩和舒张功能。
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| 关 键 词： | 动物模型 缺血再灌注 心功能 二氮嗪 |
The Protective Effect of Diazoxide Preconditioning against Myocardial Reperfusion Injury |
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| CHEN Tian-ping,ZHANG Nai-ju,CAI Xin.The Protective Effect of Diazoxide Preconditioning against Myocardial Reperfusion Injury[J].Applied Journal Of General Practice,2010,8(5):539-541. |
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| Authors: | CHEN Tian-ping ZHANG Nai-ju CAI Xin |
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| Institution: | CHEN Tian-ping,ZHANG Nai-ju,CAI Xin.Department of Cardiovascular Disease,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China |
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| Abstract: | Objective The study was aimed to investigate the protective effect of diazoxide preconditioning against myocardial IRI in rats in vivo.Methods 36 healthy male SD rats were randomly divided into 4 groups(n=9 each).Myocardial IRI injury model was prepared by ligating the LAD of rat.The index of cardiac function was recorded at the different time of before and after reperfusion.The infract size was measured by stained with TTC.The content of CK-MB and LDH in blood was Examined.Results After the LAD was ligatur... |
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| Keywords: | Experimental animal models Reperfusion injury Heart function Diazoxide |
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