| 噁丙嗪分散片的研制及溶出度 |
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| 引用本文： | 陈鹰,盛莉,高武保,宋琪,汤韧. 噁丙嗪分散片的研制及溶出度[J]. 中国医院药学杂志, 2001, 0(2) |
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| 作者姓名： | 陈鹰 盛莉 高武保 宋琪 汤韧 |
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| 作者单位： | 广州军区武汉总医院 湖北武汉430070(陈鹰，盛莉，高武保，宋琪)，广州军区武汉总医院 湖北武汉430070(汤韧) |
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| 摘 要： | 目的 :制备卟恶丙嗪分散片 ,并将其与另两种市售片剂的溶出度进行比较。方法 :通过实验获得处方和工艺 ,制定质量标准和溶出度测定方法 ,并对其进行质量评价和溶出度比较。结果 :本品完全符合英国药典中有关分散片的要求 ,其溶出参数 (m =0 .5 7,t50 =0 .5 1min ,td=0 .97min)与另两种市售片剂间差异存在极显著性。结论 :卟恶丙嗪分散片比另两种市售片剂崩解快、分散均匀度好、溶出快而完全。
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| 关 键 词： | 卟恶丙嗪分散片 制备 溶出度 质量标准 |
Study of oxaprozin dispersible tablets and comparison on its dissolution |
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| CHEN Ying,SHENG Li,GAO Wu-Bao,et al. Study of oxaprozin dispersible tablets and comparison on its dissolution[J]. Chinese Journal of Hospital Pharmacy, 2001, 0(2) |
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| Authors: | CHEN Ying SHENG Li GAO Wu-Bao et al |
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| Abstract: | OBJECTIVE:To prepare oxaprozin dispersible tablets,and the dissolution rate of it was compared with the other two commericial tablets. METHODS:The oxaprozin dispersible tablet was prepared . Also estimate of its quality and comparison on dissolution were carried out. RESULTS:The preparation completely conformed to the quality standard for dispersible tablet stated in the british pharmacopoeia.The parameters of dissolution between oxaprozin dispersible tablets and the other two commericial tablets were greatly significant. CONCLUSIONS:The oxaprozin dispersible tablets was characteristic of rapid disintegration,uniform dispersion,fast and complete dissolution.It would be a new dosage form of developmental worth. |
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| Keywords: | oxaprozin dispersible tablets preparation quality standard dissolution rate |
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