| 男性无精子或少精子患者YRRM基因检测 |
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| 引用本文： | 周作民,郑英.男性无精子或少精子患者YRRM基因检测[J].临床检验杂志,1998,16(6):327-329. |
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| 作者姓名： | 周作民 郑英 |
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| 作者单位： | 南京医科大学组胚教研室 |
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| 摘 要： | ＹＹＲＭ（ｙｃｈｒｏｍｓｏｍｅＲＮＡｒｅｃｏｇｎｉｔｉｏｎｍｏｔｉｆ）为ＡＺＦ的生要候选成分。应用ＰＣＲ方法检测了５０例正常男子、２３６例无精子症和８２例严重少精子症男子基因组ＤＮＡ中的ＹＲＲＭ１和ＹＲＲＭ２基因，发现中国男子无ＹＲＲＭ２基因，２１例无精子症和３例严重少精子症患者有ＹＲＲＭ１的丢失。
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| 关 键 词： | 无精子症 男性不育症 无精子因子 聚合酶链反应 |
Detection of YRRM gene in azoospermic and oligozoospermic men |
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| ZHOU Zuomin,ZHENG Ying,SHA Jiahao,LIN Min,WANG Lirong,ZHU Hu,ZHOU Qian.Detection of YRRM gene in azoospermic and oligozoospermic men[J].Chinese Journal of Clinical Laboratory Science,1998,16(6):327-329. |
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| Authors: | ZHOU Zuomin ZHENG Ying SHA Jiahao LIN Min WANG Lirong ZHU Hu ZHOU Qian |
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| Abstract: | YRRM is one of the the important candidates for azoospermia factor(AZF).PCR was used to analysis YRRM1 and YRRM2 gene in 50 fertile men,236 azoospermic men and 82 oligozoospermic men.The results showed that there was no YRRM2 gene in chinese men.In azoospermic men,tweenty one had the deletion of YRRM1.In oligozoospermic men,three had the deltion of YRRM1.The results indicated that PCR assay can be used in the detection of YRRM1 gene and the method is very useful for clinical diagnosis of azoospermia and oligozoospermia. |
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| Keywords: | Azoospermia Azoospermia factor PCR |
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