| Th17/Treg失衡与炎症性肠病的关系 |
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| 引用本文： | 葛婷,唐志鹏,王亮,张亚利. Th17/Treg失衡与炎症性肠病的关系[J]. 世界华人消化杂志, 2010, 18(7) |
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| 作者姓名： | 葛婷 唐志鹏 王亮 张亚利 |
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| 作者单位： | 上海中医药大学附属龙华医院消化内科上海中医药大学脾胃病研究所,上海市,200032;上海中医药大学附属龙华医院消化内科上海中医药大学脾胃病研究所,上海市,200032;上海中医药大学附属龙华医院消化内科上海中医药大学脾胃病研究所,上海市,200032;上海中医药大学附属龙华医院消化内科上海中医药大学脾胃病研究所,上海市,200032 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 炎症性肠病(inflammatory bowel disease.IBD)的病因和发病机制尚未完全明确,肠道黏膜免疫系统异常反应所导致的炎症过程在发病中起重要作用.辅助性T细胞17(T helper 17 cells,Th17)可介导慢性炎症和自身免疫性疾病的发生,调节性T细胞(regulatory T cell,Treg)有抑制自身免疫的功能,二者存在相互转化的关系.有研究表明Th17/Treg转化平衡是维持肠道免疫稳态的重要因素,这可能是导致人类IBD的原因之一.最近研究表明TGF-β,IL-6和维甲酸(retinoic acid,RA)可能是调控二者平衡关系的重要因素.肠道菌群(intestinal flora)与IBD的发生发展关系密切,益生菌(probiotics)对IBD的治疗作用成为研究的热点.深化对Th17/Treg转化调控关系的研究是当前重要的研究课题.
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| 关 键 词： | 辅助性T细胞17 调节性T细胞 炎症性肠病 |
Relationship between Th17/Treg imbalance and inflammatory bowel disease |
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| Ting Ge,Zhi-Peng Tang,Liang Wang,Ya-Li Zhang. Relationship between Th17/Treg imbalance and inflammatory bowel disease[J]. World Chinese Journal of Digestology, 2010, 18(7) |
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| Authors: | Ting Ge Zhi-Peng Tang Liang Wang Ya-Li Zhang |
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| Affiliation: | Ting Ge,Zhi-Peng Tang,Liang Wang,Ya-Li Zhang,Department of Gastroenterology,Longhua Hospital & Institute of Digestive Diseases,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China |
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| Abstract: | The etiology and pathogenesis of inflammatory bowel disease (IBD) remain incompletely understood. Inflammatory process caused by abnormal intestinal mucosal immune responses plays an important role in the pathogenesis of IBD. T helper 17 (Th17) cells mediate chronic inflammation and autoimmune diseases, while regulatory T (Treg) cells suppress autoimmunity. There is an interrelationship between Th17 cells and Treg cells. Some studies have shown that Th17/Treg balance is critical in maintaining intestinal im... |
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| Keywords: | T helper 17 cell Regulatory T cell Inflammatory bowel disease |
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