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| 黄芪通过促进滤泡辅助性T细胞活性抑制小鼠肾细胞癌生长 | |
| 引用本文： | 蔡晨,徐沈倩,杜婷婷,刘玲,蒲瑾,董勤. 黄芪通过促进滤泡辅助性T细胞活性抑制小鼠肾细胞癌生长[J]. 第二军医大学学报, 2021, 42(6): 651-656. DOI: 10.16781/j.0258-879x.2021.06.0651 |
| 作者姓名： | 蔡晨 徐沈倩 杜婷婷 刘玲 蒲瑾 董勤 |
| 作者单位： | 海军军医大学(第二军医大学)长海医院特需诊疗科,上海 200433;武警上海市总队医院肾内科,上海 201103 |
| 基金项目： | 上海市自然科学基金面上项目, |
| 摘 要： | 目的 探讨黄芪通过促进滤泡辅助性T细胞(Tfh细胞)活性抑制肾细胞癌生长的作用.方法 取56只BALB/c小鼠建立肾细胞癌模型,并随机平均分为黄芪治疗组和对照组.黄芪治疗组小鼠每天通过管饲法予0.5 mg/g黄芪提取物干预,对照组则每天给予相同体积的纯净水.两组建模后第0、9、12、15、18、21天分别处死3只小鼠,... |
| 关 键 词： | 黄芪 滤泡辅助性T细胞 肾细胞癌 白细胞介素21 |
| 收稿时间： | 2020-05-30 |
| 修稿时间： | 2021-01-25 |
Astragalus membranaceus inhibits renal cell carcinoma growth by promoting follicular helper T cell activity in mice |
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| CAI Chen,XU Shen-qian,DU Ting-ting,LIU Ling,PU Jin,DONG Qin. Astragalus membranaceus inhibits renal cell carcinoma growth by promoting follicular helper T cell activity in mice[J]. Former Academic Journal of Second Military Medical University, 2021, 42(6): 651-656. DOI: 10.16781/j.0258-879x.2021.06.0651 | |
| Authors: | CAI Chen XU Shen-qian DU Ting-ting LIU Ling PU Jin DONG Qin |
| Affiliation: | Department of Special Clinic,Changhai Hospital,Naval Medical University Second Military Medical University,Department of Special Clinic,Changhai Hospital,Naval Medical University Second Military Medical University,Department of Special Clinic,Changhai Hospital,Naval Medical University Second Military Medical University,Department of Special Clinic,Changhai Hospital,Naval Medical University Second Military Medical University,Department of Special Clinic,Changhai Hospital,Naval Medical University Second Military Medical University,Department of Nephrology, Shanghai Corps Hospital, Chinese People''s Armed Police Forces |
| Abstract: | Objective To explore the effect and mechanism of astragalus inhibiting renal cell tumor by promoting follicular helper T cell activity. Methods A mouse model of renal cell carcinoma was established, the effect of astragalus on the growth of renal cell tumors and the effects on Tfh were examined. Results The tumor growth of mice in the astragalus group was significantly slower, accompanied by an increase in Tfh tumor infiltration. The kinetic analysis of Tfh migration showed that the slowdown of tumor growth coincided with the increase of Tfh infiltration. In addition, the expression level of IL-21 in Tfh cells in the Astragalus treatment group was significantly higher than that in the control group. Furthermore, the level of tumor-infiltrating CD8 + T cells was positively correlated with the ratio of tumor-infiltrating Tfh cells and the level of IL-21 expression by Tfh cells. Conclusion These data indicate that astragalus treatment can lead to slower growth of renal cell carcinoma and exert anti-tumor immune effects through Tfh. |
| Keywords: | astragalus follicular helper T cell renal cell tumor IL-21 |
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