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Postoperative inflammation and insulin resistance in relation to body composition,adiposity and carbohydrate treatment: A randomised controlled study |
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| Authors: | Nilanjana Tewari Sherif Awad František Duška Julian P. Williams Andrew Bennett Ian A. Macdonald Dileep N. Lobo |
| Affiliation: | 1. Gastrointestinal Surgery, Nottingham Digestive Diseases Centre, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen''s Medical Centre, Nottingham NG7 2UH, UK;2. The East-Midlands Bariatric and Metabolic Institute (EMBMI), Derby Teaching Hospitals NHS Foundation Trust, Royal Derby Hospital, Derby DE22 3NE, UK;3. Department of Anaesthesia and Intensive Care, Kralovske Vinohrady University Hospital and The Third Faculty of Medicine, Prague, Czech Republic;4. Department of Critical Care, Nottingham University Hospitals NHS Trust, Queen''s Medical Centre, Nottingham NG7 2UH, UK;5. FRAME Laboratory, School of Life Sciences, University of Nottingham, Queen''s Medical Centre, Nottingham NG7 2UH, UK;6. School of Life Sciences, University of Nottingham, Queen''s Medical Centre, Nottingham NG7 2UH, UK;7. MRC/ARUK Centre for Musculoskeletal Ageing Research, University of Nottingham, Queen''s Medical Centre, Nottingham NG7 2UH, UK |
| Abstract: | |
| Keywords: | Metabolic response Carbohydrate Obesity Insulin resistance Abdominal surgery Inflammation ADIPOQ Adipose c1Q and collagen domain containing BMI Body mass index CEBP CCAAT enhancer binding protein CIDEA Cell death inducing DFFA-like effector A CRP C-reactive protein CT computed tomography DAVID database for annotation visualisation and integrated discovery DXA dual X-ray absorptiometry FFA free fatty acid FOXO forkhead box O IPA Ingenuity pathway analysis IR insulin resistance IL interleukin KEGG Kyoto encyclopaedia of genes and genomes MYD88 myeloid differentiation primary response 88 MURF 1 muscle ring finger 1 PACS picture archiving and communication system PDK pyruvate dehydrogenase kinase PI3K/Akt1 phosphotidyl inositol 3-kinase/protein kinase B PPAR peroxisome proliferator activated receptor SOD1 superoxide dismutase TAG triacylglycerol TNF-α tumour necrosis factor α TRIM 63 tripartite motif containing 63 RXR retinoid X receptor VL vastus lateralis |
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