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| 大剂量甲氨蝶呤治疗原发性中枢神经系统淋巴瘤的血药浓度监测及不良反应分析 | |
| 引用本文： | 崔向丽,林松,朱乐亭,武迎磊,赵志刚. 大剂量甲氨蝶呤治疗原发性中枢神经系统淋巴瘤的血药浓度监测及不良反应分析[J]. 中国临床药理学杂志, 2011, 27(3) |
| 作者姓名： | 崔向丽 林松 朱乐亭 武迎磊 赵志刚 |
| 作者单位： | 1. 首都医科大学附属北京天坛医院,药剂科,北京,100050 2. 首都医科大学附属北京天坛医院,神经外科,北京,100050 3. 邢台市第三医院药剂科,河北,邢台,054000 |
| 摘 要： | 目的 分析大剂量甲氨蝶吟(HD-MTX)(抗代谢性抗肿瘤药)治疗原发性中枢神经系统淋巴瘤(PCNSL)的血药浓度特点,并对其血药浓度进行监测.方法 对本院收治的19例PCNSL患者,进行50例次HD - MTX化疗,并监测化疗后不同时间点MTX血药浓度,综合分析血药浓度特点及其与患者性别、年龄及MTX剂量的相关性,并分析不良反应的发生和处理.结果 MTX化疗后,利用亚叶酸钙(CF)解毒后,大部分患者MTX血药浓度能在66 h降至安全浓度(0.05 μml·L-1以下).MTX消除与患者年龄及其剂量有相关性,与性别无关.在使用CF解救及血药浓度监侧和充分水化、碱化的情况下,HD-MTX方案未发生严重不良反应.结论 化疗后,监测MTX血药浓度并适时、适量给予CF解救,是保证HD-MTX临床用药安全的关键因素. |
| 关 键 词： | 原发性中枢神经系统淋巴瘤 甲氨蝶吟 血药浓度 药物不良反应 |
Plasma concentration and adverse drug reaction analysis of high-dose methotrexate in patients with primary central nervous system lymphoma |
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| CUI Xiang-li,LIN Song,ZHU Yue-ting,WU Ying-Lei,ZHAO Zhi-gang. Plasma concentration and adverse drug reaction analysis of high-dose methotrexate in patients with primary central nervous system lymphoma[J]. The Chinese Journal of Clinical Pharmacology, 2011, 27(3) | |
| Authors: | CUI Xiang-li LIN Song ZHU Yue-ting WU Ying-Lei ZHAO Zhi-gang |
| Affiliation: | CUI Xiang-li1a,LIN Song1b,ZHU Yue-ting1a,WU Ying-lei2,ZHAO Zhi-gang1a(1.a.Department of Pharmacy,b.Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China,2.Department of Pharmacy,The Third Hospital of Xingtai,Xingtai 054000,Hebei Province,China) |
| Abstract: | Objective To study plasma concentration and adverse drugs reaction(ADR) of high-dose methotrexate(HD-MTX) administered in patients with primary central nervous system lymphoma(PCNSL) and to improve the efficacy and safety of HD-MTX administration.Methods A total 50 cases of HD-MTX were administered to 19 patients with PCNSL in our hospital,and these cases were collected from 2009/01 to 2010/07.The plasma samples were collected and the plasma concentrations of MTX were detected at different times.The covaria... |
| Keywords: | primary central nervous system lymphoma methotrexate plasma concentration adverse drugs reaction |
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