染色体异态性与不良孕产史关系的探讨

目的:探讨染色体异态性与不良孕产史的关系。方法:对有不良孕产史的155例夫妇(不良孕产史组)和孕前检查的145对夫妇(正常体检组)进行外周血染色体核型分析,分析两组的染色体异态性发生率。结果:排除其他染色体异常后,不良孕产史组染色体异态性的发生率为11.61%,正常体检组染色体异态性的发生率为2.41%,两组比较差异有统计学意义。结论:有不良孕产史的人群染色体异态性的发生率明显高于普通人群。染色体异态性与不良孕产史有相关性。

Discussion on the relationship between chromosomal heteromorphism and adverse pregnancy history

Objective:To explore the relationship between chromosomal heteromorphism and adverse pregnancy history.Methods:Chromosomal karyotype analysis of peripheral blood was conducted in 155 couples with adverse pregnancy history(adverse pregnancy history group) and 145 couples receiving prepregnant examination(normal physical examination group);the incidences of chromosomal heteromorphism in the two groups were analyzed.Results:After excluding the other chromosomal abnormalities,the incidences of chromosomal heteromorphism in adverse pregnancy history group and normal physical examination group were 11.61% and 2.41%,respectively,there was statistically significant difference between the two groups.Conclusion:The incidence of chromosomal heteromorphism in the population with adverse pregnancy history was statistically significantly higher than that in general population.There is a correlation between chromosomal heteromorphism and adverse pregnancy history.