Review of use of postnatal corticosteroids in evolving or established bronchopulmonary dysplasia |
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| Affiliation: | 1. Pediatric Clinic, University of Brescia and Spedali Civili di Brescia, Brescia, Italy;2. Physiatry Unit, University of Brescia and Spedali Civili di Brescia, Brescia, Italy;3. Research Center of Systemic Autoimmune and Autoinflammatory Diseases and Behcet''s Disease Clinic, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Siena, Italy;1. Institute for Process Control and Innovative Energy Conversion, Mannheim University of Applied Sciences, Mannheim, Germany;2. hte GmbH, Heidelberg, Germany;3. Institute of Thermal, Environmental and Natural Products Process Engineering, Freiberg University of Mining and Technology, Freiberg, Germany;1. Clinical Operational Research Unit, University College London, London, United Kingdom;2. Sense About Science, London, United Kingdom;3. Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom;4. Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge, Cambridge, United Kingdom |
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| Abstract: | ![]()
Bronchopulmonary dysplasia (BPD) is a condition that affects a significant proportion of infants born prematurely. Whilst there have been advances in many aspects of neonatal respiratory care the rates of BPD remain relatively static. Much effort has been put into exploring the role of corticosteroids in potentially reducing inflammation in the developing lung; however, research has been hindered by concerns regarding adverse side–effect profiles and difficulties recruiting adequate numbers to power the results. Currently, two strategies are gaining popularity: low-dose dexamethasone after 7 days of age to facilitate ventilator weaning and prophylactic physiological hydrocortisone use from the first day of life. However, use in practice is limited whilst awaiting full-powered randomised trials. This article briefly discusses the evidence for each approach. |
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| Keywords: | bronchopulmonary dysplasia (BPD) postnatal corticosteroids prematurity |
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