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Intravenous administration of alendronate counteracts theIn vivo effects of glucocorticoids on bone remodeling |
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| Authors: | F. Falcini S. Trapani M. Ermini M. L. Brandi |
| Affiliation: | (1) Present address: Rheumatology Unit, Department of Pediatrics, University of Florence Medical School, Via Luca Giordano 13, Florence, Italy;(2) Endocrine Unit, Department of Physiopathology, University of Florence Medical School, Florence, Italy |
| Abstract: | The purpose of the investigation was to test the use of alendronate in the therapy of children affected by chronic rheumatic diseases and symptomatic drug-induced osteoporosis. Two courses of alendronate were intravenously administered to four girls with vertebral fractures that were glucocorticoid induced. Improvement of back pain and bone mineral density increase evaluated by DXA and conventional spine X-rays were observed. Our study supports the ABD-induced improvement of the negative effects of long-term therapy on bone mineral density in children with chronic rheumatic diseases. |
| Keywords: | Alendronate Steroids Osteoporosis Rheumatic diseases |
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