| 绿茶多酚对纤溶酶原激活物抑制剂-1表达影响 |
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| 引用本文： | 叶晓蕾, 刘健, 孟依, 衣卫杰, 范之良, 应晨江. 绿茶多酚对纤溶酶原激活物抑制剂-1表达影响[J]. 中国公共卫生, 2009, 25(3): 277-278. DOI: 10.11847/zgggws2009-25-03-12 |
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| 作者姓名： | 叶晓蕾 刘健 孟依 衣卫杰 范之良 应晨江 |
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| 作者单位： | 1.华中科技大学公共卫生学院营养与食品卫生学系, 武汉430030;;2.温洲医学院环境与公共卫生学院 |
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| 摘 要： | 目的 观察绿茶多酚(GTPs)对牛主动脉内皮细胞(BAECs)纤溶酶原激活物抑制剂-1(PAI-1)表达的影响。方法 采用蛋白免疫印迹(Western blot)检测细胞中PAI-1表达水平,酶联免疫吸附实验(ELISA)检测细胞培养液中PAI-1含量。结果 GTPs可使BAECs中PAI-1的表达和释放降低,且呈一定的时间和浓度依赖性。其中GTPs作用4 h时PAI-1表达开始显著降低(P<0.05),至作用8 h时抑制PAI-1表达最为明显(P<0.05)。随着GTPs浓度的升高,抑制效应增强,40μg/ml GTPs的抑制作用最为明显(P<0.05)。结论 GTPs可以抑制BAECs中PAI-1的表达和释放,可能具有一定的调节纤溶系统活性的功能。
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| 关 键 词： | 绿茶多酚(GTPs) 牛主动脉内皮细胞(BAECs) 纤溶酶原激活物抑制剂-1(PAI-1) |
| 收稿时间： | 2008-06-21 |
Inhibitory effect of green tea polyphenols on plasminogen activator inhibitor-1 expression |
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| YE Xiao-lei, LIU Jian, MENG Yi, . Inhibitory effect of green tea polyphenols on plasminogen activator inhibitor-1 expression[J]. Chinese Journal of Public Health, 2009, 25(3): 277-278. DOI: 10.11847/zgggws2009-25-03-12 |
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| Authors: | YE Xiao-lei LIU Jian MENG Yi |
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| Affiliation: | 1.Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China |
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| Abstract: | Objective To investigate the inhibitory effect of green tea polyphenols(GTPs)on the regulation of plasminogen activator inhibitor-1(PAI1)expression inbovine artery endothelial cells(BAECs).Methods PAI-1 expression was measured by Western blot and ELISA.Results GT Psdecreased BAECs PAI-1 expression and secretion in a time and concentration-dependent manner.After incubation for 8 h,GTPs decreased PAI1 expression significantly(P<0.05).40 μg/ml GTPs reduced PAI-1 expression obviously(P<0.05).Conclusion GTPs can repress PAI-1 expression and secretion from endothelial cells,which may contribute to cardiovascular protection. |
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| Keywords: | green tea polyphenols bovine artery endothelial cells plasm inogen activator inhibitor-1 |
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