加替沙星治疗急性细菌感染86例

目的评价加替沙星治疗急性细菌性感染的有效性和安全性。方法采用随机对照多中心平行开放的试验设计，将152例呼吸系统、泌尿系统及皮肤软组织感染患者随机分为A组（86例）和B组（66例），A组静脉滴注加替沙星（200mg，每12h一次，B组静脉滴注左氧氟沙星（200mg，每12h一次），疗程均为7～14d。结果A组和B组临床有效率分别为86．05％（74／86）和81．82％（54／66），细菌清除率分别为89.19％（66／74）和75．00％（42／56），细菌药物敏感试验敏感率分别为78．38％（58／74）和67．86％（38／56），均未发现明显不良反应。结论加替沙星治疗细菌所致的呼吸系统、泌尿系统及皮肤软组织感染安全有效。

Observation of Curative Effect of Gatifloxacin in Treatment of Acute Bacterial Infections of 86 Cases

Objective To evaluate the curative effect and safety of gatifloxacin in the treatment of acute bacterial infections.Methods A randomized comparative open multicenter trial was conducted.152 patients with bacterial infections of respiratory system,urinary system and skin soft tissues were randomly divided into Group A (86 cases) and Group B (66 cases).Group A were treated with gatifloxacin injection 200 mg,intravenous drip,q.12 h;Group B were treated with levofloxacin injection 200 mg,intravenous drip,q.12 h.The course of treatment for both groups was 7-14 d.Results The overall clinical effective rates of Group A and Group B were 86.05%(74/86) and 81.82%(54/66) respectively (P > 0.05);the bacterial clearance rates of the 2 groups were 89.19%(66/74) and 75.00%(42/56) respectively (P < 0.05);the bacterial susceptible rates of the 2 groups were 78.38%(58/74),67.86%(38/56) respectively (P < 0.05).No adverse effects were found in both groups.Conclusion Gatifloxacin injection is effective and safe in the treatment of bacterial infection of respiratory system,urinary system and skin soft tissues.