| 疟疾防治药物的研究——Ⅸ.2,4-二氨基-6-[N-(取代苄基)-N-(取代氨基甲基)氨基]-喹唑啉类衍生物的合成 |
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| 引用本文： | 郑克勤.疟疾防治药物的研究——Ⅸ.2,4-二氨基-6-[N-(取代苄基)-N-(取代氨基甲基)氨基]-喹唑啉类衍生物的合成[J].药学学报,1983,18(5):384-387. |
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| 作者姓名： | 郑克勤 |
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| 作者单位： | 上海医药工业研究院 |
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| 摘 要： | In searching for new antimalarial agents ten new compounds of 2,4-diamino-6-N-(substituted benzyl)-N-(substituted aminomethyl)-amino]-quinazoline have been synthesized. Preliminary screening results showed that only one (Ⅳ6) of these compounds displayed a slight degree of antimalarial activity against plasmodium berghei in mice. The intermediate compound (Ⅰ2) showed suppressive effect on plasmodium berghei in mice and prophylactic activity against plasmodium gallinaceum in chicken.
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| 关 键 词： | 2 4-二氨基-6-[N-(取代苄基)-N-(取代氨基甲基)-氨基]-喹唑啉 Mannich反应 抗疟作用 |
| 收稿时间： | 1982-03-25 |
Studies on antimalarials. IX. Synthesis and antimalarial activity of 2,4-diamino-6-(N-(substituted benzyl)-N-(substituted aminomethyl)-amino) quinazolines |
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| ZHENG Ke-qin.Studies on antimalarials. IX. Synthesis and antimalarial activity of 2,4-diamino-6-(N-(substituted benzyl)-N-(substituted aminomethyl)-amino) quinazolines[J].Acta Pharmaceutica Sinica,1983,18(5):384-387. |
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| Authors: | ZHENG Ke-qin |
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| Abstract: | In searching for new antimalarial agents ten new compounds of 2,4-diamino-6-N-(substituted benzyl)-N-(substituted aminomethyl)-amino]-quinazoline have been synthesized. Preliminary screening results showed that only one (Ⅳ6) of these compounds displayed a slight degree of antimalarial activity against plasmodium berghei in mice. The intermediate compound (Ⅰ2) showed suppressive effect on plasmodium berghei in mice and prophylactic activity against plasmodium gallinaceum in chicken. |
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| Keywords: | Mannich reaction Antimalarial 2 4-Diamino-6-[N-(substituted benzyl)-N-(substituted aminomethyl)-amino]-quinazolines |
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