| 原发性肝癌组织中SSTR亚型1-3mRNA的表达 |
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| 引用本文： | 张弘,江枫,魏群,张喜梅,黄介飞.原发性肝癌组织中SSTR亚型1-3mRNA的表达[J].陕西医学杂志,2006,35(3):294-296. |
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| 作者姓名： | 张弘 江枫 魏群 张喜梅 黄介飞 |
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| 作者单位： | 南通大学附属医院消化内科,南通,226001 |
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| 摘 要： | 目的了解肝细胞肝癌组织中生长抑素受体(SSTR)亚型1-3基因的表达情况。方法采用RT-PCR法检测了48例肝细胞肝癌患者癌组织和癌旁组织中生长抑素受体亚型1-3mRNA的表达。结果48例肝细胞肝癌患者的癌组织和癌旁组织中SSTR1mRNA表达的阳性率分别为18.7%(9/48)和31.3%(16/48);SSTR2mRNA表达的阳性率分别为91.6%(44/48)和93.7%(45/48);SSTR3mRNA表达的阳性率分别为20.8%(11/48)和50.0%(24/48)。结论肝细胞肝癌组织中大多数有一种以上生长抑素受体亚型的表达,其中SSTR2为主要表达亚型。
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| 关 键 词： | 肝肿瘤/免疫学 生长抑素受体 基因表达调控 mRNA |
| 收稿时间： | 2005-10-25 |
| 修稿时间： | 2005-10-25 |
Somatostatin Receptor Subtypes1-3 mRNA Expression in Primary Hepatic Carcinoma |
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| Zhang Hong, Jiang Feng, Wei Qun, et al.Somatostatin Receptor Subtypes1-3 mRNA Expression in Primary Hepatic Carcinoma[J].Shaanxi Medical Journal,2006,35(3):294-296. |
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| Authors: | Zhang Hong Jiang Feng Wei Qun |
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| Institution: | Nantong 226001 |
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| Abstract: | Objective: To investigate SSTR subtypes 1-3mRNA expression in tissue of primary hepatic carcinoma. Methods: The expression of SSTR subtypes 1-3mRNA in the tumor tissues of hepatic carcinoma and the adjacent tissues of cancer in 48 patients with primary hepatic carcinoma was examined by RT-PCR. Results: The positive rate of expression of SSTR 1 mRNA was 18.7%(9/48) in the tissues of hepatic carcinoma and 31.3%(16/48) in the adjacent tissues of cancers. The positive rate of expression of SSTR2 mRNA was 91.6%(44/48) and 93.7%(45/48) in the tissue of hepatic carcinoma and the adjacent tissue of cancer respectively.The positive rate of expression of SSTR3 mRNA was 20.8%(11/48) and 50% (24/48)respectively. Conclusion: There is more than one SSTR subtype genes expression in tumor tissues of primary hepatic carcinoma, and SSTR2 is the main subtype for expression in tissues of primary hepatic carcinoma. |
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| Keywords: | Liver Neoplasms/immunology Somatostation Receptor Subtypes Gene Expression Regulation mRNA |
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