| 注射用头孢拉定对双黄连粉针药动学的影响 |
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| 引用本文： | 苏美英.注射用头孢拉定对双黄连粉针药动学的影响[J].齐鲁药事,2007,26(6):369-370. |
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| 作者姓名： | 苏美英 |
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| 作者单位： | 泰安市中心医院,山东,泰安,271000 |
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| 摘 要： | 目的测定双黄连粉针中绿原酸在大鼠体内的药动学参数。方法利用建立的高效液相色谱法测定大鼠单独静脉注射双黄连粉针及与头孢拉定合用后绿原酸在大鼠体内的血药浓度,采用药动学程序Topfit2.0进行统计处理,计算非室模型药动学参数。结果单用双黄连粉针后绿原酸的药动学参数:t210.5h,ke1.37h-1,AUC0-t6.98μg.h.mL-1,MRT0.43h,Cltot111.0mL.min-1.kg-1,Vz5.01L.min-1.kj-1;合用头孢拉定后绿原酸的药动学参数:t210.53h,ke1.33h-1,AUC0-t8.07μg.h.mL-1,MRT0.45h,Cltot99.3mL.mL-1.kg-1,Vz4.50L.min-1.kg-1。结论头孢拉定不影响大鼠体内绿原酸的药动学过程。
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| 关 键 词： | 头孢拉定 双黄连粉针 高效液相色谱法 药动学参数 |
| 文章编号： | 1672-7738（2007）06-0369-02 |
The Effect of Cefradine for Injection on Pharmacokinetics of Shuanghuanglian Injection |
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| SU Mei-ying.The Effect of Cefradine for Injection on Pharmacokinetics of Shuanghuanglian Injection[J].qilu pharmaceutical affairs,2007,26(6):369-370. |
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| Authors: | SU Mei-ying |
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| Institution: | Taian central hospital,Taian,271000 |
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| Abstract: | OBJECTIVE To determine the effect of cefradine for injection on pharmacokinetics of shuanghuanglian injection.METHODS HPLC was used for the determination of chlorogenic acid in rats after iv shuanghuanglian injection or combined with cefradine for injection.Non-compartment pharmacokinetic parameters of chlorogenic acid were analyzed by topfit 2.0.RESULTS Pharmacokinetic parameters of chlorogenic acid after iv shuanghuanglian injection:t1/20.5h,ke1.37h-1,AUC0-t6.98μg·h·mL-1,MRT0.43h,Cltot111.0mL·min-1·kg-1,Vz5.01L·min-1·kj-1;after combination with cefradine injection:t1/20.53h,ke 1.33h-1,AUC0-t8.07μg·h·mL-1,MRT0.45h,Cltot99.3mL·mL-1·kg-1,Vz4.50L·min-1·kg-1.CONCLUSION Cefradine may not change remarkably pharmacokinetic parameters of chlorgenic acid according to the statistics anslysis. |
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| Keywords: | Cefradine shanghuanglian injection HPLC pharmacokinetic parameters |
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