内镜逆行胰胆管造影介导光动力疗法治疗胆管癌研究进展

胆管癌恶性程度高，早期诊断困难，绝大多数患者被确诊时已不可行手术切除，患者生存质量低，生存 周期短，传统放射治疗和化学药物治疗效果欠佳且不良反应大，因而缺乏有效的控制手段。内镜逆行胰胆管造影 (endoscopic retrograde cholangiopancreatography，ERCP)是诊断和治疗胆道疾病的重要手段，而光动力疗法(photodynamic therapy，PDT)作为胆管癌的一种新的局部治疗方法优势明显。近年来，ERCP介导的PDT治疗胆管癌的研究在国外逐 渐兴起。其可有效缓解胆管癌患者的症状，提高生存质量，延长生存期，有望成为治疗胆管癌的新手段。

Research progress in endoscopic retrograde cholangiopancreatography-mediated photodynamic therapy for cholangiocarcinoma

Th e malignant degree of cholangiocarcinoma is high, and the early diagnosis is diffi cult. Th e vast majority of patients are unresectable when they are diagnosed. Th e patients have low quality of life and short survival cycle. Traditional radiotherapy and chemotherapy have poor effi cacy and lead toside effects, and thus lack effective control measures for cholangiocarcinoma. Endoscopic retrograde cholangiopancreatography (ERCP) is an important method for diagnosing and treating biliary tract diseases. Photodynamic therapy (PDT) is a new local treatment for cholangiocarcinoma. In recent years, ERCP-mediated PDT treatment of cholangiocarcinoma has gradually emerged. ERCPmediated PDT can effectively relieve the symptoms of patients with cholangiocarcinoma, improve the patients’ quality of life, prolong the survival cycle, and is expected to become a new treatment for cholangiocarcinoma.