胎膜早破孕妇绒毛膜羊膜炎与CRP、白细胞计数相关性研究

目的 探讨孕妇血清C反应蛋白（CRP）、白细胞计数与胎膜早破绒毛膜羊膜炎的相关性.方法 对2011年1月-2012年1月我院收治并分娩的胎膜早破孕足月初产妇55例（观察组）及同期无胎膜早破孕足月初产妇60例（对照组）进行血清CRP及白细胞计数测定.结果 观察组及对照组血清CRP、白细胞计数及其阳性率比较差异均有统计学意义（P＜0.01）.观察组经病理检查又分为绒毛膜羊膜炎亚组38例及非绒毛膜羊膜炎亚组17例,两组CRP、白细胞计数比较差异有统计学意义（P ＜0.01）；CRP阳性率比较差异有统计学意义（P＜0.05）.观察组治疗2d后CRP较治疗前明显下降（P＜0.05）,而白细胞计数仅轻度下降（P＞0.05）.结论 检测胎膜早破孕妇血清CRP及白细胞计数可早期发现绒毛膜羊膜炎,对及早处理、改善妊娠预后有重要的临床意义.

Relationship between Chorioamnionitis with C-reactive Protein and White Blood Cell Count in Pregnant Women with Premature Rupture of Memberane

Objective To explore the relationship between chorioamnionitis with c-reactive protein （CRP） and white blood cell count （WBC） in pregnant women with premature rupture of memberane （PROM）.Methods A total of 55 full-term primiparas with PROM in our hospital during January 2011 and January 2012 were selected as observation group,and 60 full-term primiparas without PROM at the same period were selected as control group.The values of serum CRP and WBC in the two groups were detected.Results The differences in values of serum CRP,WBC,and comparison of positive rates of CRP and WBC in the two groups were statistically significant （P ＜0.01）.Patients in observation group were divided into chorioamnionitis group （group A,n =38）and non-chorioamnionitis group （group B,n =17） by pathologic results,and the differences in values of CRP and WBC in group A and B were statistically significant （P ＜0.01） ; the difference in positive rate of CRP in the two groups was also statistically significant （P ＜0.05）.After treatment for 2 d,the CRP value was significantly decreased,and the WBC value was slightly decreased in observation group,compared with those before treatment （P ＞ 0.05）.Conclusion The chorioamnionitis tends to be easily diagnosed by detecting the values of serum CRP and WBC in pregnant women with PROM,which has clinical significance in early treatment and improvement of pregnancy prognosis.