抵抗素与老年糖尿病合并高血压的相关性研究

目的 探讨抵抗素对老年糖尿病合并高血压的影响及其与相关代谢指标的关系.方法 将153例2型糖尿病分为合并高血压组70例和单纯糖尿病组83例,并选取同期健康体检55例老年人作为健康对照组.均测定体质量指数（BMI）、空腹血糖（FBG）、餐后2h血糖（2 h PG）、空腹胰岛素（FINS）、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）及抵抗素水平,分析抵抗素与其他各项代谢指标的相关性.结果 与健康对照组比较,合并高血压组和单纯糖尿病组2hPG、BMI、FBG、FINS、HOMA-IR、HbA1c、TG及血清抵抗素水平均明显升高,HDL-C明显下降,差异均有统计学意义（P ＜0.01,P＜0.05）;与单纯糖尿病组比较,合并高血压组HOMA-IR、血清抵抗素水平明显升高,差异有统计学意义（P＜0.05）;血清抵抗素水平与BMI、HOMA-IR呈显著正相关（r =0.278,P=0.034;r =0.492,P=0.000）.结论 老年2型糖尿病合并高血压患者血清抵抗素水平明显升高,提示血清抵抗素可能通过某种机制和途径促进糖尿病患者的动脉硬化进程,促发高血压.

A Correlation Study on the Resistin and Elderly Patients with Diabetes Complicated with Hypertension

Objective To explore the effect of resistin in elderly patients with diabetes complicated with hypertension,and the relationship with metabolic parameters.Methods A total of 153 patients with type 2 diabetes mellitus were divided into complication of hypertension group （group A,n =70） and simple diabetes group （group B,n =83）,and other 55 elderly healthy people taking physical examinations were selected as control group.The levels of body mass index （BMI）,fasting plasma glucose （FBG）,2 h postprandial blood glucose （2 h PG）,fasting insulin （FINS）,glycosylated hemoglobin （HbA1c）,insulin resistance index （HOMA-IR）,total cholesterol （TC）,low density lipoprotein cholesterol （LDL-C）,high density lipoprotein cholesterol （HDL-C）,triglyceride （TG） and resistin levels were detected,and the correlation between resistin and other metabolism indexes were analyzed.Results The levels of 2 h PG,BMI,FBG,FINS,HOMA-IR,HbA1c,TG and serum resistin in group A were significantly higher,and HDL-C level was significantly lower than those in control group,and the differences were statistically significant （P ＜ 0.01,P ＜0.05）; the levels of HOMA-IR and serum resistin were significantly higher in group A than those in group B,and the differences were statistically significant （P ＜0.05）; there was a significantly positive correlation between serum resistin level with BMI and HOMA-IR （r =0.278,P =0.034; r =0.492,P =0.000）.Conclusion The serum resistin level in elderly patients with type 2 diabetes mellitus complicated with hypertension is significantly higher,which suggests that serum resistin may promote atherosclerotic process in patients with diabetes mellitus by some mechanisms and pathways,which contributes to occurrence of hypertension.