Population Structure and Antimicrobial Resistance of Invasive Serotype IV Group B Streptococcus,Toronto, Ontario,Canada |
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| Authors: | Sarah Teatero Allison McGeer Aimin Li Janice Gomes Christine Seah Walter Demczuk Irene Martin Jessica Wasserscheid Ken Dewar Roberto G. Melano Nahuel Fittipaldi |
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| Affiliation: | Public Health Ontario, Toronto, Ontario, Canada (S. Teatero, A. Li, J. Gomes, C. Seah, R.G. Melano, N. Fittipaldi); ;University of Toronto, Toronto (A. McGeer, R.G. Melano, N. Fittipaldi); ;Mount Sinai Hospital, Toronto (A. McGeer, R.G. Melano); ;Public Health Agency of Canada, Winnipeg, Manitoba, Canada (W. Demczuk, I. Martin); ;McGill University, Montreal, Quebec, Canada (J. Wasserscheid, K. Dewar); ;Genome Quebec Innovation Centre, Montreal (J. Wasserscheid, K. Dewar) |
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| Abstract: | ![]()
We recently showed that 37/600 (6.2%) invasive infections with group B Streptococcus (GBS) in Toronto, Ontario, Canada, were caused by serotype IV strains. We report a relatively high level of genetic diversity in 37 invasive strains of this emerging GBS serotype. Multilocus sequence typing identified 6 sequence types (STs) that belonged to 3 clonal complexes. Most isolates were ST-459 (19/37, 51%) and ST-452 (11/37, 30%), but we also identified ST-291, ST-3, ST-196, and a novel ST-682. We detected further diversity by performing whole-genome single-nucleotide polymorphism analysis and found evidence of recombination events contributing to variation in some serotype IV GBS strains. We also evaluated antimicrobial drug resistance and found that ST-459 strains were resistant to clindamycin and erythromycin, whereas strains of other STs were, for the most part, susceptible to these antimicrobial drugs. |
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| Keywords: | bacterial infection invasive bacterial disease group B Streptococcus streptococci Streptococcus agalactiae bacteria serotype IV multilocus sequence typing whole-genome sequencing antimicrobial resistance population structure Toronto Canada |
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