纤维蛋白原和 D-二聚体在妊高征中的应用价值

目的探讨正常晚孕妇女和妊娠高血压综合征（妊高征）患者血浆中纤维蛋白原（Fm）和D-二聚体（D—D）水平及其临床意义。方法采用SysmexcA-7000全自动血凝仪检测500例正常晚期妊娠孕妇（正常晚孕组）、200例妊高征孕妇（妊高征组）和100例健康育龄期非妊娠女性（正常未孕组）血浆中FIB和D—D水平。结果正常晚孕妇女、妊高征患者血浆中FIB、D—D水平分别高于健康未孕妇女，妊高征患者的FIB、D—D水平高于正常晚孕妇女，两组比较差异有统计学意义（P〈0．01）。结论正常临产孕妇处于高凝状态，妊高征患者血栓前状态更明显。检测FIB、D—D对妊高征的诊断、预后评估有重要的应用价值。

The clinical value of fibrinogen and D-dimer for pregnancy induced hypertension women

Objective To explore the changes of fibrinogen（Fib） and D-dimer（D-D） in normal pregnancy and pregnancy induced hypertension（PIH） women. Methods Sysmex CA-7 000 was applied to measure the level of Fib and D-D in 500 cases of normal late pregnancy women, 200 cases of PIH women and 100 cases of non- pregnancy women. Results The level of Fib and D-D in normal late pregnancy women and PIH women were obviously higher than non-pregnancy women. The level of Fib and D-D in PIH women were ob- viously higher than normal late pregnancy women （P〈0.O1）. Conclusions Normal late pregnancy women were in hypercoagulable state, PIH women were in obvious prethrombotic state. Fib and D-D had important clinical value in diagnosis and prognosis assessment for PIH.