| 华蟾蜍毒素对离体豚鼠输精管的作用 |
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| 引用本文： | 韩永晶,张力,崔荣芬. 华蟾蜍毒素对离体豚鼠输精管的作用[J]. 药学学报, 1992, 27(4): 252-255 |
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| 作者姓名： | 韩永晶 张力 崔荣芬 |
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| 作者单位： | 天津医学院药理教研室，张家口医学院药理教研室，天津医学院药理教研室 天津 30070，张家口 075029，天津 30070 |
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| 摘 要： | 华蟾蜍毒素(华蟾素)使离体豚鼠输精管产生剂量依赖性收缩反应,利血平化豚鼠输精管及冷藏输精管对华蟾素反应减弱。给酚妥拉明、维拉帕米后,输精管对华蟾素反应均受抑制,溴苄胺可使反应潜伏期缩短。结果提示华蟾素收缩输精管反应可能与其促进肾上腺素能神经末稍NA释放有关。
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| 关 键 词： | 华蟾蜍毒素 输精管 去甲肾上腺素 |
| 收稿时间： | 1991-06-04 |
EFFECT OF CINOBUFAGIN ON THE GUINEA PIG VAS DEFERENS AND ITS MECHANISM OF ACTION |
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| YJ Han,L Zhang,RF Cui. EFFECT OF CINOBUFAGIN ON THE GUINEA PIG VAS DEFERENS AND ITS MECHANISM OF ACTION[J]. Acta pharmaceutica Sinica, 1992, 27(4): 252-255 |
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| Authors: | YJ Han L Zhang RF Cui |
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| Affiliation: | Department of Pharmacology, Tianjin Medical College. |
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| Abstract: | Cinobufagin, one of the active principles extracted from toad venom, was studied on the isolated vas deferens of the guinea pig. The preparation was suspended in a bath containing 10 ml Krebs solution. Isometric tension of vas deferens was recorded on polygraph with a force displacement transducer. Cinobufagin caused a long lasting contraction of the vas deferens of the guinea pig at concentrations of 15-50 mumol/L. The contraction was inhibited following reserpinization and cold storage treatment. The cinobufagin induced contraction was partly blocked by pretreatment with phentolamine and verapamil. These results suggest that the cinobufagin induced contraction of vas deferens might be related to an action which promotes release of NA from the adrenergic nerve terminals. |
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| Keywords: | Cinobufagin Vas deferens Nor adrenaline |
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